Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 511-520 of 1,773 results
Neural Regeneration Research, 2023 • December 21, 2022
This article reviews research on the mechanistic roles of purinergic receptors in spinal cord injury, highlighting the potential role of purinergic receptors as interventional targets for neural repai...
KEY FINDING: Activation of adenosine A1 and A3 receptors can exert neuroprotective effects after CNS injury by inhibiting glutamate release and reducing Ca2+ accumulation.
Neural Regeneration Research, 2023 • December 21, 2022
This study investigates the role of macrophage migration inhibitory factor (MIF) in the production of the chemokine CCL2 by astrocytes following spinal cord injury (SCI). The findings demonstrate that...
KEY FINDING: MIF levels significantly increase at the lesion site after SCI, coinciding with elevated CCL2 production.
Neural Regeneration Research, 2023 • October 11, 2022
This study explored the protective role of PARP14 in SCI, finding that PARP14 expression increases at the injury site in a mouse model of SCI, and its knockdown worsens SCI. Both in vivo and in vitro ...
KEY FINDING: PARP14 expression is upregulated in spinal cord tissues after SCI, suggesting a compensatory mechanism.
Neural Regen Res, 2023 • January 30, 2023
Spinal cord injury leads to neuronal death, with ferroptosis being a key contributor to dysfunction. Emerging treatments like MSC, EV, and TMS therapy offer hope by potentially inhibiting neuronal dea...
KEY FINDING: Ferroptosis, a form of cell death, significantly contributes to neurological dysfunction following spinal cord injury.
Redox Biology, 2023 • March 20, 2023
This study elucidates the protective role of Git1 in spinal cord ischemia-reperfusion injury (SCIRI), demonstrating that Git1 deletion impairs functional recovery in mice. The research uncovers a nove...
KEY FINDING: Deletion of Git1 in mice resulted in poorer recovery of spinal cord motor function after SCIRI, indicating Git1's protective role.
Mediators of Inflammation, 2023 • April 10, 2023
This study investigated the effects of AdipoRon on neuropathic pain (NeuP) in mice, focusing on its impact on microglia and the AdipoR1/AMPK pathway. The results showed that AdipoRon alleviated mechan...
KEY FINDING: AdipoRon alleviated mechanical nociception in spared nerve injury (SNI) mice, indicating a reduction in pain sensitivity.
Int. J. Mol. Sci., 2023 • April 11, 2023
The study demonstrates an altered profile of cytokine-producer T cells in patients with chronic SCI, with notable changes throughout the course of the disease. Significant variations in cytokine produ...
KEY FINDING: Patients with late-chronic SCI (SCI-LCP) exhibit a significant increase in the spontaneous expression of IL-10 by CD4 cells in comparison to healthy controls (HC) and SCI-SP.
J. Pers. Med., 2023 • April 2, 2023
This study investigates plasma levels of malondialdehyde (MDA), a marker of lipid peroxidation, in patients with chronic spinal cord injury (SCI) stratified by time since injury. The results demonstra...
KEY FINDING: Patients with SCI had significantly higher plasma levels of MDA than healthy control subjects.
Glia, 2023 • September 1, 2023
This study demonstrates that the injured spinal cord remains remarkably dynamic for months after injury, exhibiting continuous myelin repair and concurrent demyelination. It identifies that glutamater...
KEY FINDING: New myelin generation peaks at 3 months post-injury but continues for at least 6 months after SCI, indicating a prolonged remyelination response.
Top Spinal Cord Inj Rehabil, 2023 • April 1, 2023
This study investigated the differential expression of vascular-related miRNAs in circulating endothelial microvesicles (EMVs) in adults with spinal cord injury (SCI). The study found that adults with...
KEY FINDING: Circulating EMV levels were significantly higher in adults with SCI compared to uninjured adults.