Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 501-510 of 1,773 results
J Cell Mol Med, 2020 • August 17, 2020
This study investigates the effects of mechanical stress and decompression on autophagy and apoptosis after spinal cord injury (SCI) in a rabbit model. The results indicate that decompression reduces ...
KEY FINDING: Decompression reduces intramedullary pressure (IMP) after spinal cord injury (SCI), with piotomy showing the most significant decrease.
Int. J. Mol. Sci., 2024 • June 29, 2024
The study investigated the effects of intramuscular pulsed radiofrequency (PRF) on complicated pain using a two-stage animal study. The first stage examined the effects of PRF on muscle and sciatic ne...
KEY FINDING: PRF upregulates brain-derived neurotrophic factor (BDNF) in the spinal cord in both groups of rats.
bioRxiv preprint, 2024 • December 6, 2024
The study investigates how different developmental origins shape the properties of V2a neurons, excitatory interneurons important for motor function, by differentiating them from hPSC-derived progenit...
KEY FINDING: Distinct progenitor origins (NEP vs. NMP) lead to differences in gene expression and chromatin accessibility in V2a neurons, even under identical differentiation conditions.
Pain Research and Management, 2022 • July 8, 2022
This study explored the relationship between pain, bone metastasis, and cytokine expression in cancer patients treated with external radiation therapy. The research aimed to identify specific cytokine...
KEY FINDING: Radiotherapy significantly improved pain scores and quality of life in cancer patients with bone metastasis.
Frontiers in Medicine, 2023 • June 8, 2023
This study aimed to explore the molecular events related to bone defect progression using bioinformatic analysis of transcriptome data and experimental validation. Key findings include the identificat...
KEY FINDING: The study identified 2057, 827, and 1,024 DEGs at 7, 14, and 21 days post injury, respectively, in critical size defects (CSD) compared to non-critical size defects (NCSD).
Journal of Traditional Chinese Medicine, 2023 • December 14, 2022
This study aimed to investigate the analgesic effects of Chinese Tuina on neuropathic pain in rats by examining synaptic structure remodeling in the spinal cord dorsal horn (SCDH). The results showed ...
KEY FINDING: Tuina and MK-801 (an NR2B antagonist) reversed CCI-induced changes in motor function and reduced mechanical and cold allodynia in rats.
Neural Regeneration Research, 2024 • February 1, 2024
This review discusses the advances in EV-based combination therapies for SCI, specifically when EVs are combined with nanoparticles, exogenous drugs, and biomaterials. These combinations aim to improv...
KEY FINDING: Combining EVs with nanoparticles, such as iron oxide nanoparticles (IONP), can improve their targeting ability to the injured spinal cord tissue, especially when guided by an external magnetic field.
European Journal of Applied Physiology, 2025 • November 22, 2024
This study aimed to determine whether evoking knee extensor (KE) muscle hypertrophy prior to FES-LEC training would further augment mitochondrial enzymatic activity than simply using FES-LEC only. The...
KEY FINDING: Both interventions demonstrated a time effect on CS (P = 0.001) with interaction between both groups (P = 0.01).
Neural Regeneration Research, 2023 • April 1, 2023
This review summarizes the progress in reprogramming astrocytes into neurons in vivo in animal models of various CNS conditions. The focus is on spinal cord injury, brain injury, Huntington’s disease,...
KEY FINDING: Astrocytes in the mature CNS can be reprogrammed into functional neurons in vivo, offering a potential avenue for nerve regeneration.
Neural Regeneration Research, 2023 • October 11, 2022
This study investigates the role of thrombin in regulating cholesterol metabolism in astrocytes following spinal cord injury (SCI) in rats. The results demonstrate that SCI-induced thrombin activation...
KEY FINDING: Spinal cord injury increases thrombin and CH25H expression in rat astrocytes.