Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 521-530 of 1,773 results
Clinical and Translational Medicine, 2023 • May 21, 2023
This study investigates the therapeutic effects of intravenous delivery of small extracellular vesicles (sEVs) derived from human mesenchymal stem/stromal cells (MSC) on body growth and motor recovery...
KEY FINDING: Intravenous delivery of human and rat MSC-sEVs improved functional motor recovery after SCI and restored normal body growth in young adult SCI rats.
Journal of Inflammation Research, 2023 • June 13, 2023
This review highlights the significant role of non-coding RNAs (ncRNAs) in regulating neuroinflammation (NI) following spinal cord injury (SCI), which subsequently influences the development of neurop...
KEY FINDING: miRNAs regulate inflammation after SCI by influencing microglia-mediated inflammation, with some miRNAs like miR-137-3p reducing pro-inflammatory factors by targeting NeuroD1. NF-κB-dependent inflammation is also modulated by miRNAs, impacting neuropathic nociceptive hyperalgesia.
J South Med Univ, 2023 • June 1, 2023
This study investigates the potential of Acetylcorynoline (Ace) to promote functional recovery after spinal cord injury (SCI) in rats by modulating the EGFR/MAPK signaling pathway to inhibit microglia...
KEY FINDING: Ace treatment significantly increased the BBB score, reduced the area of spinal cord injury, and lowered the number of activated microglia cells and the levels of pro-inflammatory cytokines.
Spinal Cord Series and Cases, 2023 • June 27, 2023
The study compared oxidative stress and antioxidant responses to high-intensity arm cranking exercise in individuals with SCI and able-bodied controls. SCI participants exhibited lower baseline levels...
KEY FINDING: SCI participants had lower baseline levels of certain antioxidants (α-carotene, β-carotene) and creatinine compared to controls.
eLife, 2023 • July 18, 2023
The study conducts a meta-analysis of genome-wide association studies (GWASs) using 22,016 Japanese individuals and identifies 14 significant loci, 8 of which were previously unreported. A Mendelian r...
KEY FINDING: Identified 14 significant loci associated with OPLL, including 8 previously unreported loci.
Mediators of Inflammation, 2023 • July 10, 2023
This study investigates the role of TMEM100 in NP using CCI and TNI rat models. It found that TMEM100 expression is significantly reduced in the DRG of rats with peripheral NP. AAV6-mediated delivery ...
KEY FINDING: TMEM100 expression is significantly reduced in the DRG of rats with peripheral neuropathic pain induced by tibial nerve injury (TNI) and chronic constriction injury (CCI).
Nature Communications, 2023 • July 7, 2023
This author correction addresses an error in the original article concerning the effects of MN-EV and MN-MSC treatments on the inflammatory response in spinal cord lesions following SCI. The correctio...
KEY FINDING: The correction clarifies that MN-MSC treatment, not MN-EV treatment, resulted in a statistically significant increase in the anti-inflammatory cytokine TGF-β.
Neurotrauma Reports, 2023 • January 1, 2023
The study aimed to investigate the role of synj1 in locomotor function recovery after SCI in ApoE4 mice. Researchers found that ApoE4 mice had higher synj1 expression and lower PIP2 levels in spinal c...
KEY FINDING: ApoE4 mice had elevated synj1 mRNA and protein levels in their spinal cords, along with lower PIP2 levels, compared to ApoE3 mice.
FUNCTION, 2023 • June 13, 2023
The study investigated the influence of genetics, age, and sex on respiratory motor plasticity induced by AIHH in healthy adults. Results showed that the APOE4 genotype, sex, and age are significant d...
KEY FINDING: Individuals heterozygous for APOE4 showed lower AIHH-induced changes in diaphragm MEP amplitudes.
Frontiers in Microbiology, 2023 • July 28, 2023
This study explored the effects of every-other-day fasting (EODF) on gut microbiota and spinal cord transcriptome dynamics in rats with spinal cord injury (SCI). The researchers used 16S rRNA sequenci...
KEY FINDING: EODF treatment led to dynamic shifts in the abundance of gut bacteria, including increases in potentially anti-inflammatory genera like Lactobacillus and decreases in pro-inflammatory genera like Bacteroides.