Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 461-470 of 1,773 results
Cellular and Molecular Neurobiology, 2024 • March 27, 2024
This study aimed to characterize gene expression and molecular mechanisms in the spinal cord of mice after SCI, identifying UHRF1 as a potential therapeutic target. Bioinformatics analysis of sequenci...
KEY FINDING: RNA sequencing analysis revealed that the immune system and various metabolic processes play crucial roles in SCI.
J South Med Univ, 2024 • April 1, 2024
This study investigates the mechanism of Jisuikang formula-medicated serum combined with SOX2 in inducing astrocyte reprogramming into neurons. The results showed that Jisuikang treatment improved mot...
KEY FINDING: Jisuikang treatment significantly improved BBB scores and performance in the inclined-plate test in SCI rats.
Frontiers in Neurology, 2024 • April 22, 2024
This review summarizes the pathological mechanisms of oxidative stress in SCI and the connection with teriparatide, exploring teriparatide's therapeutic potential. Oxidative stress in SCI involves an ...
KEY FINDING: Oxidative stress is a key factor in the secondary pathological process of SCI, leading to nerve cell death and tissue damage due to excessive free radicals.
BRAIN COMMUNICATIONS, 2024 • April 20, 2024
This longitudinal study assessed the relationship between systemic inflammation and CNS atrophy in individuals with progressive MS over 2.5 years. The findings indicate that systemic inflammation asso...
KEY FINDING: Systemic inflammation, measured by urinary neopterin levels, predicts cervical cord atrophy in individuals with progressive MS.
Cellular & Molecular Biology Letters, 2024 • May 6, 2024
This study investigates the role of ADAM8 in microglia-mediated neuroinflammation following spinal cord injury (SCI). The research demonstrates that ADAM8 promotes microglial activation, migration, an...
KEY FINDING: ADAM8 up-regulation in microglia is associated with inflammation after SCI.
Heliyon, 2024 • April 27, 2024
This study employs a multi-omics approach, integrating gene expression data and immune cell analysis to identify key genes involved in macrophage polarization in osteoarthritis (OA). Machine learning ...
KEY FINDING: Machine learning identified CSF1R, CX3CR1, CEBPB, and TLR7 as hub genes in osteoarthritis.
GMJ, 2023 • October 23, 2023
The role of miRNAs in BC metastasis to the brain represents a potential treatment approach. Hence, by investigating the complex networks of miRNA-based molecular alterations and their potential role a...
KEY FINDING: MiR-10b has been identified as a metastasis-promoting miRNA, influencing tumor invasiveness and enhancing colonization of BC cells to the brain by targeting various genes involved in cell adhesion and angiogenesis
Experimental Physiology, 2024 • May 2, 2024
This study investigates the role of ferroptosis in diabetic nephropathy (DN) and the efficacy of the ferroptosis inhibitor SRS 16-86 in DN recovery. The findings show that SRS 16-86 promotes renal fun...
KEY FINDING: SRS 16-86 could improve the recovery of renal function after DN by upregulating glutathione peroxidase 4, glutathione and system xc−light chain and by downregulating the lipid peroxidation markers and 4-hydroxynonenal.
Frontiers in Cellular Neuroscience, 2024 • May 15, 2024
This review focuses on the demyelination and remyelination after SCI, and summarizes the progress of miRNAs on OPC functions and remyelination, which might provide a potential therapeutic target for S...
KEY FINDING: miRNAs can modulate axon outgrowth, inflammation, angiogenesis, apoptosis, astrogliosis, and remyelination after SCI.
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2024 • April 17, 2024
This study used machine learning to identify differentially expressed genes in microglia after spinal cord injury (SCI), focusing on the clearance of apoptotic cells. Key genes Anxa2, Myo1e, and Spp1 ...
KEY FINDING: Microglia participate in neuroinflammation and play a significant role in the clearance mechanism of apoptotic cells following SCI.