Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 471-480 of 1,773 results
Molecular Therapy: Nucleic Acids, 2024 • June 1, 2024
This study investigates the role of neurexin 2 in cancer-induced bone pain (CIBP), finding that its expression is increased in the spinal dorsal horn (SDH) of CIBP rats and correlates with pain hypers...
KEY FINDING: Neurexin 2 expression is significantly increased in the spinal dorsal horn (SDH) of rats with cancer-induced bone pain (CIBP), and this increase is correlated with lower pain thresholds.
CNS Neurosci Ther, 2024 • May 18, 2024
This study aimed to investigate the antioxidant role of GIP on neurons and explore the possible mechanisms, particularly in the context of spinal cord injury. The results showed that GIP reduced ROS l...
KEY FINDING: GIP reduces ROS levels and protects cells from apoptosis in cultured neurons and injured spinal cord.
Journal of Orthopaedic Surgery and Research, 2023 • September 13, 2023
This research investigates the role of microglia and ferroptosis in spinal cord injury (SCI) using single-cell RNA sequencing data from mice at 3 and 14 days post-injury. The study identifies key gene...
KEY FINDING: Microglia are associated with immune system regulation at different time points after SCI and can modulate cytokine production.
Int. J. Mol. Sci., 2024 • May 24, 2024
This study investigates the neuropathological consequences of extracranial radiation therapy (ECRT) in mice, focusing on the brain and spinal cord changes following radiation exposure to the hindlimb....
KEY FINDING: ECRT induces dose-dependent changes in gene and protein expression in the brain, affecting neurotransmission, glial cell activation, and immune signaling.
bioRxiv, 2024 • June 8, 2024
This study establishes that SCI-triggered enteric pathologies are able to be modified by the intrinsic intestinal environment. The composition of the microbiome is therefore not solely responsible for...
KEY FINDING: Inulin supplementation improves gut transit and prevents ENS atrophy in a murine model of SCI.
Advanced Science, 2024 • June 19, 2024
This study investigates the potential mechanism by which Rg1-EVs promote functional recovery in the injured spinal cord. Our findings demonstrated that Rg1-EVs significantly supported the recovery of ...
KEY FINDING: Rg1-EVs significantly improved motor function recovery in spinal cord-injured mice.
Acta Neuropathologica, 2024 • June 12, 2024
This study demonstrates that ferroptosis, an iron-dependent form of cell death, contributes to secondary damage and functional loss after spinal cord injury (SCI). The study identifies key markers of ...
KEY FINDING: Increased expression of NCOA4, a key molecule involved in iron release from ferritin, was observed in the injured spinal cord after SCI.
Medicina, 2024 • June 17, 2024
This study investigated the roles of CBP and MeCP2 in neuropathic pain using a spared nerve injury (SNI) rat model. The researchers measured the expression levels of these proteins in the spinal cord ...
KEY FINDING: SNI induced a significant increase in the number of CBPs in the L4 dorsal horn of the spinal cord compared to control groups, indicating an upregulation of CBP expression after nerve injury.
Pharmaceuticals, 2024 • June 16, 2024
The study aimed to investigate the anti-inflammatory and analgesic effects of daphnetin (DAP) and explore the underlying mechanisms of action in neuropathic pain (NP). DAP treatment ameliorated the MW...
KEY FINDING: DAP treatment ameliorated the mechanical withdrawal threshold (MWT) and thermal withdrawal threshold (TWT) in CCI rats, indicating reduced pain sensitivity.
JOR Spine, 2024 • May 29, 2024
This study investigated the therapeutic effects of silibinin in a spinal cord injury (SCI) model, focusing on its potential to mitigate secondary damage through inhibiting ferroptosis. The results sho...
KEY FINDING: Silibinin significantly suppressed MDA and 4-HNE levels compared to the SCI group, indicating reduced lipid peroxidation.