Research progress on the inhibition of oxidative stress by teriparatide in spinal cord injury

Spinal cord injury (SCI) leads to further damage through a cascade of reactions, including oxidative stress. This involves an imbalance of free radicals, causing nerve cell death and tissue damage. Teriparatide, a drug used for osteoporosis, has shown potential in counteracting oxidative stress. Research is exploring its therapeutic role in SCI by targeting oxidative stress-related mechanisms. The review discusses how teriparatide may protect nerve cells by activating the Nrf2 pathway, which reduces oxidative stress and promotes neuronal repair after SCI.

• 1
  Oxidative stress is a key factor in the secondary pathological process of SCI, leading to nerve cell death and tissue damage due to excessive free radicals.
• 2
  The Nrf2/ARE signaling pathway plays a neuroprotective role in the early stages of SCI by reducing or eliminating ROS and reducing cell oxidative stress.
• 3
  Teriparatide can activate the Nrf2 pathway, increasing the expression of antioxidant proteins like HO-1 and SOD2, thus inhibiting oxidative stress and improving nerve function.