Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 401-410 of 1,773 results
Pharmaceuticals, 2023 • September 7, 2023
The study explores the effects of ∆8-THC on neuronal cell death and recovery in a trauma-injured NSC-34 motoneuron cell line model. Traumatic scratch injury was induced, and cells were pretreated with...
KEY FINDING: ∆8-THC triggers cytoskeletal remodeling, potentially through activation of the Janus Kinase Signal Transducer and Activator of Transcription (JAK/STAT) signaling pathway and the Mitogen-Activated Protein (MAP) Kinase signaling pathway.
Frontiers in Cell and Developmental Biology, 2023 • September 12, 2023
This study investigates the therapeutic potential of bone marrow mesenchymal stem cell exosomes (BMSC-Exo)-derived microRNA-216a-5p (miR-216a-5p) in treating spinal cord injury (SCI) in rats. The resu...
KEY FINDING: BMSC-Exo treatment improved locomotor performance in SCI rats, as evidenced by increased BBB scores.
Heliyon, 2023 • September 23, 2023
This study provides in vivo evidence that RIT1 plays an important role(s) in the control of cerebral lipid levels, resulting in robust region-specific lipid changes. We also detected a selective reduc...
KEY FINDING: RIT1 loss is associated with altered lipid levels in the central nervous system (CNS), including myelin-associated lipids within the corpus callosum (CC).
International Journal of Biological Sciences, 2023 • September 11, 2023
This study investigates the therapeutic potential of tofacitinib (TOF), a JAK inhibitor, for spinal cord injury (SCI) by examining its effects on microglial polarization and the JAK/STAT signaling pat...
KEY FINDING: TOF effectively improves motor dysfunction caused by spinal cord injury in rats, indicating its potential to promote functional recovery.
The Journal of Neuroscience, 2023 • December 6, 2023
The study identifies a spinal-specific super enhancer (SS-SE) that plays a critical role in the development and maintenance of neuropathic pain. SS-SE drives the expression of Ntmt1 and Prrx2 in dorsa...
KEY FINDING: A spinal-specific super enhancer (SS-SE) was identified that regulates CCI-induced neuropathic pain by driving Ntmt1 and Prrx2 transcription in dorsal horn neurons.
Neurosci Lett., 2023 • November 20, 2023
This study investigates the effectiveness of systemic administration of NIS-lncRNA ASO in alleviating neuropathic pain (NP) in mice with chronic constriction injury (CCI). The results demonstrate that...
KEY FINDING: Systemic administration of NIS-lncRNA ASO significantly alleviated CCI-induced mechanical allodynia, heat hyperalgesia, and cold hyperalgesia in mice.
Redox Biology, 2023 • October 10, 2023
Oxidative stress after spinal cord injury (SCI) contributes to neurological deficits. The study introduces an iridium complex, IrPHtz, designed to counteract this. IrPHtz modulates the OXR1 protein, d...
KEY FINDING: IrPHtz can modulate the Oxidation Resistance 1 (OXR1) protein levels within spinal cord tissues, thus showcasing its antioxidative potential.
iScience, 2023 • November 17, 2023
The study demonstrates that increased cell surface expression of the P2X4 receptor induces hypersensitivity to mechanical stimulation and hyperexcitability in spinal cord neurons in both male and fema...
KEY FINDING: Increased cell surface expression of P2X4 induces hypersensitivity to mechanical stimulations and hyperexcitability in spinal cord neurons of both male and female naive mice.
Neural Regeneration Research, 2024 • June 1, 2024
This study investigates the role of circ0000381 in regulating microglia/macrophage pyroptosis following spinal cord injury (SCI). The findings suggest that circ0000381 upregulation after SCI may be a ...
KEY FINDING: Circ0000381 expression is upregulated in the spinal cord of rats after SCI and in LPS-treated microglia/macrophages in vitro.
PeerJ, 2023 • October 31, 2023
This study investigates the therapeutic potential of human umbilical cord mesenchymal stem cell-derived small extracellular vesicles (hUC-MSCs-sEVs) in repairing the blood-spinal cord barrier (BSCB) a...
KEY FINDING: hUC-MSCs-sEVs mitigate BSCB disruption in rats after SCI, as demonstrated by reduced Evans blue and FITC-dextran fluorescence intensity in the injured spinal cord.