Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 391-400 of 1,773 results
Neurosci Lett, 2023 • September 25, 2023
This study investigates the effects of pramipexole and dexpramipexole on chronic allodynia and cytokine expression in mice with sciatic nerve damage. The researchers hypothesized that both compounds w...
KEY FINDING: Both pramipexole and dexpramipexole significantly reduced allodynia in mice within one hour of intravenous injection, although the effect was temporary, with allodynia returning after 24 hours.
Journal of Translational Medicine, 2023 • August 2, 2023
Sciatic nerve crush led to motor dysfunction, reduction in exploration behavior, and a robust increase in mechanical and thermal hypersensitivity that were found to be mediated by neuroinflammation, n...
KEY FINDING: HBOT alleviates mechanical and thermal hypersensitivity and motor dysfunction following sciatic nerve crush (SNC).
Acta Neuropathologica Communications, 2023 • September 28, 2023
This study investigates the role of acid sphingomyelinase (A-SMase) in Alzheimer's disease (AD) pathology, focusing on its impact on microglia and astrocyte activation, extracellular vesicle (EV) secr...
KEY FINDING: A-SMase is activated in microglia by Aβ oligomers via activation of the TLR4 receptor, leading to the release of proinflammatory factors.
FEBS Open Bio, 2023 • January 1, 2023
This study identified a significant increase in SOCE-mediated calcium influx following injury-induced neuropathic pain. Pharmacologically inhibition of SOCE by both SKF96365 and YM-58483 had an analge...
KEY FINDING: SOCE-mediated calcium influx was significantly increased following nerve injury in neuropathic rats.
Journal of Nanobiotechnology, 2023 • August 4, 2023
This study analyzed 359 articles from Web of Science (WoS) published between 1991 and May 2023 to assess the global research trends in extracellular vesicles (EVs) for spinal cord injury (SCI). The an...
KEY FINDING: The number of publications on EVs in SCI has experienced explosive growth starting in 2015.
Front. Cell. Neurosci., 2023 • August 9, 2023
Ferroptosis plays a significant role in ACNSI, particularly in secondary injury mechanisms, with mitochondrial dysfunction being a key contributor. Malfunctioning mitochondria can trigger oxidative st...
KEY FINDING: ACNSI can induce mitochondrial dysfunction, highlighting the importance of the mitochondrial connection to ferroptosis.
CNS Neurosci Ther, 2024 • January 1, 2024
This study investigates the role of HDAC6 inhibition in promoting microvascular endothelial cells (MECs) to phagocytize myelin debris and reduce inflammation following spinal cord injury (SCI). The re...
KEY FINDING: MECs phagocytize myelin debris via IgM opsonization, which promotes secretion of inflammatory factors. IgG-opsonized myelin debris does not have the same effect.
PeerJ, 2023 • August 28, 2023
This study investigates the protective effects of low-dose lipopolysaccharide (LPS) on spinal cord injury (SCI) in rats and PC12 cells. The findings demonstrate that low-dose LPS alleviates SCI-induce...
KEY FINDING: Low-dose LPS pretreatment improved nerve function and reduced tissue damage in rats with SCI.
Redox Biology, 2023 • September 7, 2023
This study investigates the role of mitochondrial quality control (MQC) in neuronal ferroptosis after spinal cord injury (SCI) and the therapeutic potential of mesenchymal stem cells (MSCs). The resea...
KEY FINDING: Neurons primarily suffer from ferroptosis in SCI, as shown by single-cell RNA sequencing.
Communications Biology, 2023 • September 1, 2023
This study investigates the role of miRNAs in neurogenic heterotopic ossifications (NHOs) following spinal cord injury (SCI) using a mouse model and patient cells. It identifies an osteo-suppressive mi...
KEY FINDING: SCI induces mineralization and exacerbates osteo-chondrogenic markers expression in cardiotoxin (CDTX) damaged muscle.