Iridium metal complex targeting oxidation resistance 1 protein attenuates spinal cord injury by inhibiting oxidative stress-associated reactive oxygen species

Spinal cord injury (SCI) often leads to neurological deficits due to oxidative stress. This study explores the use of an iridium complex (IrPHtz) to combat this. IrPHtz modulates the Oxidation Resistance 1 (OXR1) protein, demonstrating antioxidative potential by eliminating reactive oxygen species (ROS) and preventing apoptosis. In SCI-afflicted mice, IrPHtz protected spinal cord neurons, promoted regrowth, restored electrical signaling, and improved motor performance, suggesting its therapeutic potential.

• 1
  IrPHtz can modulate the Oxidation Resistance 1 (OXR1) protein levels within spinal cord tissues, thus showcasing its antioxidative potential.
• 2
  Molecular docking analysis revealed π stacking within the IrPHtz-OXR1 complex, enhancing OXR1 expression and reducing oxidative stress.
• 3
  In SCI-afflicted mice, IrPHtz protected spinal cord neurons, promoted their regrowth, restored electrical signaling, and improved motor performance.