Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 411-420 of 1,773 results
Molecules, 2023 • October 31, 2023
The study compared nitric oxide (NO) production in injured and intact brain regions using EPR spectroscopy in rats with brain and spinal cord injuries. A reduction in NO content was observed in both i...
KEY FINDING: Seven days after brain and spinal cord injury, there was an 84% reduction in NO content in the injured brain regions.
European Journal of Medical Research, 2023 • November 3, 2023
ScRNA-seq has emerged as a powerful tool that has revolutionised our understanding of neurological disorders, providing high-resolution insights into cellular heterogeneity and gene expression profile...
KEY FINDING: In recurrent glioblastoma multiforme (GBM), scRNA-seq analysis revealed overexpression of stemness and cell-cycle-related genes, decreased microglial proportions, high expression of vascular endothelial growth factor A (VEGF-A), increased blood–brain barrier permeability, and activation of the O6-methylguanine deoxyribonucleic acid (DNA) methyltransferase-related pathway.
Molecular Pain, 2023 • November 10, 2023
The study investigates the role of HDAC6 in neuropathic pain (NP) induced by chronic constriction injury (CCI) in mice, finding that HDAC6 expression is upregulated in the spinal cord following CCI. T...
KEY FINDING: HDAC6 expression is upregulated in the spinal cord following chronic constriction injury (CCI).
Advanced Science, 2024 • November 27, 2023
This study investigates the role of the cGas-Sting signaling pathway in microglia after spinal cord injury (SCI). The findings indicate that Sting is activated in microglia after SCI, triggering an in...
KEY FINDING: Sting expression is increased in activated microglia after SCI, and knockout of Sting in microglia improves neurological function recovery after SCI.
International Journal of Stem Cells, 2024 • November 29, 2023
This review summarizes the role of MSCs-Exos in SCI treatment, including regulating immune responses, promoting angiogenesis, activating autophagy and inhibiting apoptosis, regulating the permeability...
KEY FINDING: MSCs-Exos can reduce A1 neurotoxic astrocytes to improve the outcome of SCI. Wang et al. (88) found that intravenous administration of MSCs-Exos exerts anti-inflammatory and neuroprotective effects in a rat model of SCI
Frontiers in Immunology, 2023 • November 8, 2023
This review describes the current understanding of the JAK-STAT signaling in neuroendocrine homeostasis and diseases, together with the rationale for targeting at this pathway for the treatment of SCI...
KEY FINDING: The JAK/STAT pathway is involved in the proliferation and differentiation of neural stem cells, promoting the regeneration of astrocytes and inducing the differentiation of neurons and oligodendrocytes.
Neural Regeneration Research, 2024 • November 8, 2023
This study investigates the role of fibroblast growth factor 21 (FGF21) in ferroptosis following spinal cord injury (SCI) in rats. The study found that FGF21 levels decrease after SCI, while heme oxyg...
KEY FINDING: FGF21 levels decrease in spinal cord tissue after SCI, while ferroptosis is aggravated.
Regenerative Therapy, 2024 • January 1, 2024
This study elucidates the mechanism by which MSCs-EVs, enriched with miR-26b-5p, attenuate spinal cord injury (SCI) by targeting the KDM6A/NOX4 axis. The findings indicate that MSCs-EVs deliver miR-26...
KEY FINDING: MSCs-EVs alleviate motor dysfunction, inflammation, and oxidative stress in SCI rats, suggesting a therapeutic effect.
Biology Direct, 2023 • December 6, 2023
This study demonstrated the critical role of spinal Apoe in the maintenance of inflammatory pain. Apoe knockout exerts regulatory effects on the function of astrocytes, microglial cells, and neurons, ...
KEY FINDING: Apoe levels were markedly upregulated at 2 h and on days 1 and 3 post-CFA treatment, and Apoe was exclusively expressed in the astrocytes.
Cell Journal (Yakhteh), 2023 • November 1, 2023
This study investigated the impact of spinal cord injury (SCI) on the gene expression of transmembrane proteins and the release of extracellular vesicles (EVs) in blood, using both in silico and in vi...
KEY FINDING: Significant upregulation of Grm1, Nrg1, CD63, Enpp3, and Cxcr4 was observed between the acute and control groups at the RNA level.