Genetics Research

KEY FINDING: Emodin elevated response latency and delayed the onset of mechanical hyperalgesia in rats with CCI on days 7, 14, and 21.

KEY FINDING: AQP4 is crucial in spinal cord water homeostasis, evidenced by its presence in astrocytic endfeet and the glia limitans.

KEY FINDING: H2S exhibits neuroprotective properties by reducing oxidative stress, lipid peroxidation, and neuroinflammation. It also inhibits processes associated with apoptosis, autophagy, ferroptosis, and pyroptosis.

KEY FINDING: Ionomycin dose-dependently induces pathological changes in myelin and pronounced axonal spheroid formation.

KEY FINDING: Autophagy flow is blocked in the spinal dorsal horn of mice with chronic constriction injury (CCI), indicating impaired cellular cleaning processes during neuropathic pain.

KEY FINDING: Repeated mild blast traumatic brain injury (rmbTBI) results in mitochondrial impairment diffusely throughout the brain.

KEY FINDING: LncRNA Mirt2 mediated the inflammatory response after SCI by inhibiting NF-κB and p38MAPK signaling pathways, suppressing apoptosis, and reducing the release of pro-inflammatory cytokines (e.g., TNF-α and IL-6) through sponge miR-429.

KEY FINDING: Argatroban effectively promoted neurological function recovery after spinal cord injury in rats.

KEY FINDING: BSA is adsorbed on PPPy/I with a high affinity, indicated by an adsorption constant of K = 24.35 μ−1.

KEY FINDING: hUCMSC-derived exosomes notably alleviate spinal cord injury and cell apoptosis in a rat model.