Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 371-380 of 1,773 results
Arch Med Sci, 2023 • May 1, 2023
This study investigated the role of miR-19a in spinal cord injury (SCI) using a rat model. Microarray analysis identified miR-19a as one of the most deregulated miRNAs after SCI. The researchers found...
KEY FINDING: Microarray analysis revealed that several miRs, including miR-19a, were abnormally expressed after SCI in rats.
Molecular Pain, 2023 • January 1, 2023
This study investigates the preventive and therapeutic effects of a sub-anesthetic dose of propofol on chronic post-ischemic pain (CPIP) in mice, a model for complex regional pain syndrome (CRPS). The...
KEY FINDING: Propofol attenuates mechanical allodynia induced by CPIP in mice, both when administered pre-emptively and post-operatively.
bioRxiv preprint, 2023 • June 9, 2023
This study demonstrates that astrocyte SOCE is necessary and sufficient for central sensitization and the development of hypersensitivity in Drosophila. The research adds new understanding to the astr...
KEY FINDING: Astrocytes exhibit SOCE-dependent calcium signaling three to four days after nerve injury in a Drosophila model.
CNS Neuroscience & Therapeutics, 2023 • May 28, 2023
This study investigates the role of HIF-1α in promoting MIF production from astrocytes following spinal cord injury (SCI) in rats. The results demonstrate that SCI-induced activation of HIF-1α leads t...
KEY FINDING: Spinal cord injury elevates HIF-1α and MIF protein levels at the injury site, with both being abundantly expressed in spinal cord astrocytes.
Cellular and Molecular Neurobiology, 2023 • June 25, 2023
This review discusses known and unknown aspects of BMMNCs, including the cell harvesting, administration route and dose; mechanisms of action; and their applications in neurological diseases, includin...
KEY FINDING: BMMNCs have been applied in clinical trials for stroke, cerebral palsy, spinal cord injury, traumatic brain injury, amyotrophic lateral sclerosis, autism spectrum disorder and epilepsy.
Cells, 2023 • June 14, 2023
The study developed a new method to isolate small extracellular vesicles (sEVs) from male and female wild-type and 5xFAD mouse brains to investigate the sex-specific functions of sEVs in Alzheimer’s di...
KEY FINDING: A novel method for isolating sEVs from brain tissues was developed, ensuring cell integrity and minimizing contamination from cellular debris.
Scientific Reports, 2023 • July 5, 2023
This study investigates the potential protective effects of rapamycin, an autophagy activator, on lung injury following acute spinal cord injury (ASCI) in rats. The researchers hypothesized that rapam...
KEY FINDING: Rapamycin pretreatment significantly reduced lung damage after ASCI, including cell death, inflammatory exudation, hemorrhage, and pulmonary congestion, at 12 and 48 hours post-injury.
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2023 • March 24, 2023
This study aimed to investigate the effect of FGF23 on neuronal apoptosis, inflammation and locomotion recovery, as well as its underlying mechanism in experimental SCI models. In SCI model rats, FGF2...
KEY FINDING: FGF23 overexpression decreased cell apoptosis and inflammation in H2O2-stimulated neurons by activating the PI3K/AKT signaling pathway.
Journal of Neuroinflammation, 2023 • July 1, 2023
This study investigates the role of endothelial progenitor cell-derived exosomes (EPC-EXOs) in macrophage polarization following spinal cord injury (SCI) and explores the underlying mechanisms. The re...
KEY FINDING: EPC-EXOs decreased pro-inflammatory macrophage markers and increased anti-inflammatory markers after SCI.
Cells, 2023 • May 22, 2023
This study investigates the role of LRP1 in mitochondrial function following traumatic brain injury (TBI) and oxidative stress. Using both in vivo (mtD2g mice) and in vitro (WT and LRP1 knockout MEF c...
KEY FINDING: Oxidative stress increased the quantity of fragmented and spherical-shaped mitochondria in the injury core of the ipsilateral cortex following TBI.