Research progress on long non‑coding RNAs for spinal cord injury

Spinal cord injury (SCI) is a complex central nervous system disease with an unsatisfactory prognosis, often accompanied by multiple pathological processes. However, the underlying mechanisms of action of this disease are unclear, and there are no suitable targeted therapeutic options. Long non-coding RNA mediates a variety of neurological diseases and regulates various biological processes, including apoptosis and autophagy, inflammatory response, microenvironment, and oxidative stress. To further understand the mechanism of long non-coding RNA action in spinal cord injury and develop preventive and therapeutic strategies regarding spinal cord injury, this review outlines the current status of research between long non-coding RNAs and spinal cord injury and potential long non-coding RNAs target-ing spinal cord injury.

• 1
  LncRNA Mirt2 mediated the inflammatory response after SCI by inhibiting NF-κB and p38MAPK signaling pathways, suppressing apoptosis, and reducing the release of pro-inflammatory cytokines (e.g., TNF-α and IL-6) through sponge miR-429.
• 2
  LncRNA NEAT1 is the molecular sponge of miR-211-5p and BCL2L11, and the knockdown of lncRNA NEAT1 can reduce the production of inflammatory cytokines IL-6, IL-1β, and TNF-α through miR-211-5p/MAPK1 and miR-29a/BCL2L11 pathways and alleviate SCI inflammation
• 3
  LncRNA CASC9 acts as a ceRNA of miR-383-5p to regulate the LDHA-mediated Nrf2/HO-1 signaling pathway, and CASC9 overexpression can reduce SCI oxidative stress and inflammatory response.