Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 331-340 of 1,773 results
Cells, 2023 • February 6, 2023
This study investigates the therapeutic potential of gene therapy targeting Fgfr4 over-expression in mature astrocytes following SCI in adult mice. The results show that Fgfr4 over-expression in astro...
KEY FINDING: Fgfr4 over-expression in astrocytes immediately after SCI improves motor function recovery; however, it may display sexual dimorphism.
Exp Neurol, 2023 • May 1, 2023
This study investigates the direct effects of MAO inhibitors on brain mitochondrial bioenergetics and ROS production. The research focuses on clorgyline (MAO-A inhibitor), deprenyl/rasagiline (MAO-B i...
KEY FINDING: Selective inhibition of MAO-A by clorgyline increased mitochondrial oxygen consumption rate in State V(CI) respiration compared to vehicle treatment.
ASN Neuro, 2024 • January 1, 2024
This study analyzes the transcriptomic effects of ER stress induced by thapsigargin (TG) and tunicamycin (TM) in primary rat oligodendrocyte precursor cells (OPCs). The results show that both drugs up...
KEY FINDING: ER stress, induced by thapsigargin (TG) and tunicamycin (TM), downregulates oligodendrocyte (OL) lineage-enriched mRNAs, including those for transcription factors (TFs) that drive OL identity, such as Olig2.
Medicine, 2024 • July 12, 2024
This bibliometric study provides a comprehensive overview of research trends, hotspots, and key contributors in the field of autophagy and spinal cord injury (SCI). The analysis identifies influential...
KEY FINDING: The number of publications related to autophagy and SCI has generally increased from 2009 to 2023, peaking in 2020.
Epigenetics, 2023 • February 7, 2023
The study investigates m6A modification profiles in mRNAs and circRNAs of normal and OGD/R-treated neurons to understand epigenetic mechanisms involved in cerebral ischemia-reperfusion injury. The res...
KEY FINDING: Expression analysis revealed that the m6A levels did not affect m6A mRNA or m6A circRNA expression in neurons.
Brain Communications, 2023 • February 13, 2023
This study examined the effects of pioglitazone on mitochondrial function and cortical tissue sparing following mild brain contusion in mice. The researchers used a controlled cortical impact (CCI) mo...
KEY FINDING: Early pioglitazone treatment (0.25 h post-injury) restores maximal mitochondrial respiration in total and synaptic fractions of cortical mitochondria after mild controlled cortical impact.
Nat Neurosci, 2023 • April 1, 2023
The study identifies catecholaminergic neurons in the caudal ventrolateral medulla (cVLM) that are activated by noxious stimuli and produce bilateral feed-forward inhibition that attenuates nociceptiv...
KEY FINDING: Catecholaminergic neurons in the caudal ventrolateral medulla (cVLM) are activated by noxious stimuli.
PLOS ONE, 2023 • March 10, 2023
This study investigated the differential effects of NOX2 and NOX4 inhibition after spinal cord injury (SCI) in rodents, using NOX2 knockout mice and a NOX4 inhibitor (GKT137831). Genetic ablation of N...
KEY FINDING: NOX2 knockout mice showed significantly improved motor function at 7, 14, and 28 days post-injury compared to wild-type mice.
Neural Regeneration Research, 2023 • January 5, 2023
This study investigates the effect of photobiomodulation (PBM) on mitochondrial fission imbalance after spinal cord injury (SCI) in rats. The researchers treated rat models of SCI with PBM for 14 cons...
KEY FINDING: Photobiomodulation alleviated mitochondrial fission imbalance in spinal cord tissue in the subacute phase after spinal cord injury.
Frontiers in Neuroscience, 2023 • March 6, 2023
This review provides an overview of autophagy's role in central nervous system (CNS) trauma, specifically spinal cord injury (SCI) and traumatic brain injury (TBI). It discusses the mechanisms of auto...
KEY FINDING: Autophagy can have both protective and detrimental roles in CNS trauma, depending on the context and severity of the injury. Moderate activation of autophagy may protect neurons, while excessive autophagy can exacerbate neuronal damage.