Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 341-350 of 1,773 results
Biochemistry and Biophysics Reports, 2023 • March 13, 2023
This study investigates the therapeutic potential of hypoxia-induced exosomal circular RNA OXNAD1 from human umbilical cord mesenchymal stem cells (HucMSCs) against spinal cord ischemia reperfusion (S...
KEY FINDING: Hypoxia-HucMSCs-derived exosomal circOXNAD1 alleviated the spinal cord tissue injury in SCI, improved limb motor function, decreased production of inflammatory factors
Cells, 2023 • March 18, 2023
The study investigates whether intranasal (IN) administration of miR133b/Ago2 can achieve a therapeutic effect on spinal cord injuries (SCI) in mice. The study also determines whether a NEO100-based f...
KEY FINDING: IN delivery of miR133b/Ago2 reaches the lesion scar and co-administration of miR133b with NEO100 facilitated the cellular uptake.
J. Clin. Med., 2023 • March 8, 2023
Ferroptosis, a novel form of cell death, has become a current research hotspot since it was discovered in 2012. Various studies have confirmed that ferroptosis may play a key role in the development of...
KEY FINDING: Iron overload is an important risk factor for osteoporosis development and is positively correlated with its progression.
Sci. Adv., 2023 • March 29, 2023
This study investigates the role of the volume-regulated anion channel (VRAC), specifically its essential subunit Swell1, in ATP release from spinal microglia and its contribution to neuropathic pain ...
KEY FINDING: SWELL1-dependent VRAC directly conducts and releases ATP from cells.
Frontiers in Neuroscience, 2023 • March 14, 2023
This review explores the connection between Ferroptosis and spinal cord injury (SCI), highlighting that iron overload, ROS accumulation, lipid peroxidation, and glutamate accumulation—all associated w...
KEY FINDING: Iron overload in the motor cortex induces neuronal Ferroptosis following spinal cord injury. Iron deposition in the motor cortex was significantly increased in SCI patients compared to healthy controls.
Heliyon, 2023 • March 20, 2023
This study investigates the impact of dapsone (DDS) on inflammatory responses and functional recovery in rats following spinal cord injury (SCI). The research focuses on both acute and long-term effec...
KEY FINDING: DDS decreases GRO/KC plasma levels after moderate SCI. By 6 h after SCI, all doses of DDS had decreased GRO/KC plasma levels.
BMC Genomics, 2023 • April 3, 2023
This study investigates the role of circRNAs in the pathogenesis of spinal cord injury (SCI) using microarray analysis and bioinformatics. The research identifies a ceRNA network involving RNO_CIRCped...
KEY FINDING: SCI leads to differential expression of 414 circRNAs and 5337 mRNAs.
Current Neuropharmacology, 2023 • January 1, 2023
This study investigates the neurotoxic effects of bupivacaine, a local anesthetic commonly used in spinal anesthesia, on pregnant mice. The research aims to elucidate the underlying mechanisms, focusi...
KEY FINDING: Bupivacaine treatment in pregnant mice increases oxidative stress-mediated DNA damage and neuronal injury in the spinal cord.
CNS Neuroscience & Therapeutics, 2023 • January 1, 2023
This study aimed to investigate the potential mechanism of paeonol in the treatment of neuropathic pain. Paeonol relieves neuropathic pain by modulating microglial M1 and M2 phenotypes through the Rho...
KEY FINDING: Paeonol decreases M1 markers (IL1β, iNOS, CD32, IL6) and increases M2 markers (IL10, CD206, ARG-1) in LPS-induced microglia.
Front. Cell Dev. Biol., 2023 • March 22, 2023
This review discusses the therapeutic potential of small extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) for treating spinal cord and nerve injuries. It highlights the limitati...
KEY FINDING: Small EVs, particularly those derived from adipose tissue-MSCs (ADMSCs), offer therapeutic potential for improving neural structure after injury. They promote nerve regeneration and reduce risks associated with MSC transplantation, such as immune response and tumorigenesis.