Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 321-330 of 1,773 results
Redox Biology, 2023 • January 24, 2023
This study demonstrates that SIRT1 is highly expressed in endothelial cells of the spinal cord and that its expression decreases after SCI. Endothelial cell-specific knockout of SIRT1 exacerbates BSCB...
KEY FINDING: SIRT1 expression decreases in spinal cord endothelial cells after SCI, suggesting a potential role in BSCB disruption.
Journal of Advanced Research, 2023 • January 27, 2023
This review systematically analyzes the role and mechanism of Nischarin/IRAS in the CNS, providing references and possible targets for neurological disease treatment and broadening the direction of Ni...
KEY FINDING: Nischarin/IRAS expression in the CNS is closely associated with the regulation of brain development, especially neuronal migration.
Cell Death and Disease, 2023 • January 19, 2023
This study demonstrates that SCDEs can attenuate the inflammatory response by regulating macrophage/microglia polarization, reducing neuronal apoptosis, and promoting functional recovery after SCI. MF...
KEY FINDING: SCDEs attenuate LPS-induced inflammation in BMDMs by suppressing M1 polarization and stimulating M2 polarization, improving functional recovery in SCI rats.
Cell & Bioscience, 2023 • January 19, 2023
This study investigated the potential of activating the Ang-(1–7)/MasR axis to promote functional recovery after spinal cord injury (SCI) by regulating microglia/macrophage polarization. The results d...
KEY FINDING: Ang-(1–7) up-regulated MasR expression in macrophages under inflammatory conditions, suggesting it can play a larger role in macrophages expressing MasR under inflammatory conditions.
Neural Regeneration Research, 2023 • November 25, 2022
This study investigated the potential targets and mechanisms of photobiomodulation (PBM) for spinal cord injury (SCI) repair by analyzing the differential gene expression profile of PBM regulating mac...
KEY FINDING: Photobiomodulation inhibited STAT3 expression through increasing the expression of miR-330-5p, and that miR-330-5p binding to STAT3 inhibited STAT3 expression.
BMC Musculoskeletal Disorders, 2023 • February 3, 2023
This retrospective cohort study compared the clinical outcomes of four different femoral implants (telescopic rod, plate and screws, elastic nail, and non-elongating rod) in children with osteogenesis...
KEY FINDING: Children with Sillence type III (severe OI) had the highest revision rate and shortest implant survival period, while those with type I (mild OI) had the lowest revision rate and longest survival period.
Int. J. Mol. Sci., 2023 • February 1, 2023
This study confirms that increasing XIAP protein expression in neurons effectively reduces caspase activity and apoptotic death in neural cells exposed to deleterious stimuli. Overexpression of XIAP p...
KEY FINDING: Overexpression of hXIAP in neurons of transgenic mice (CB57hXIAP+) led to a significant increase in the number of surviving neurons after SCI, particularly in the penumbra regions around the injury epicenter.
Frontiers in Endocrinology, 2023 • January 31, 2023
This study concludes that melatonin therapy was associated with improved testicular histopathological characteristics, reproductive hormonal panel, and tissue markers of oxidative stress in male roden...
KEY FINDING: Melatonin therapy was associated with improved testicular histopathological characteristics, reproductive hormonal panel, and tissue markers of oxidative stress in male rodents with physical, ischemic, and thermal testicular injuries.
Indian Journal of Urology, 2023 • December 29, 2022
This study presents a case series and systematic review of xanthogranulomatous epididymo-orchitis (XGEO), a rare inflammatory condition affecting the male genital organs. The research analyzes clinica...
KEY FINDING: XGEO often presents as a subacute or chronic condition, predominantly affecting men in their 50s and 60s. Symptoms include swelling, tenderness, or pain in the scrotal region.
Antioxidants, 2023 • February 3, 2023
The study examined the effects of EGCG, PP242, and their combination on spinal cord injury (SCI) in rats, finding that both EGCG and PP242 improved sensory and motor functions after SCI. EGCG was foun...
KEY FINDING: EGCG and PP242 significantly improved sensory/motor functions following SCI in rats.