Oxidative stress and inflammation in the pathogenesis of neurological disorders: Mechanisms and implications

Neuroprotection is a strategy to protect the nervous system from damage, especially in neurodegenerative disorders. Oxidative stress, caused by an imbalance of ROS, is a key factor in the development of neurological disorders because the brain is vulnerable to oxidative stress. Researchers are exploring antioxidants and other molecules to reduce oxidative stress and slow the progression of brain diseases, ultimately improving the quality of life for affected individuals.

• 1
  Oxidative stress, resulting from an imbalance between ROS production and antioxidant defenses, significantly contributes to neurodegenerative diseases.
• 2
  Mitochondrial dysfunction, a common feature in neurodegenerative disorders, leads to increased ROS production and oxidative damage.
• 3
  Microglia, the primary immune cells in the CNS, play dual roles; they can worsen damage through inflammation and oxidative stress or restore neuronal balance.