Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,641-1,650 of 1,773 results
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2021 • January 1, 2021
This study examined adhesion-associated DNA methylation patterns in Schwann cells before and after peripheral nerve injury (PNI) in Wistar rats. The research identified candidate genes that may regula...
KEY FINDING: Activated Schwann cells (ASCs) exhibit a stronger proliferative capacity and adhesion compared to normal Schwann cells (NSCs).
Molecular Therapy: Nucleic Acids, 2020 • December 1, 2020
This study investigates the role of miR-135a-5p in promoting functional recovery after spinal cord injury (SCI) by targeting specific genes and downstream signaling pathways. The findings indicate tha...
KEY FINDING: MiR-135a-5p expression is significantly decreased after spinal cord injury in rats, suggesting a role in the injury response.
Cell Death Discovery, 2020 • December 1, 2020
This study investigated the therapeutic effects of gelatine nanostructured lipid carriers (GNLs) encapsulating fibroblast growth factor 15 (FGF15) in a rat model of spinal cord injury (SCI). The resea...
KEY FINDING: FGF15-GNLs significantly improved hindlimb locomotor function in rats with SCI compared to FGF15 alone, as measured by the BBB locomotion scale.
Cell Death & Disease, 2020 • December 11, 2020
The study demonstrates that δ-secretase is sufficient to promote prominent AD pathologies in wild-type hAPP/hMAPT double transgenic mice. Overexpression of δ-secretase in these mice accelerated the fo...
KEY FINDING: hAPP/hMAPT double-transgenic mice, carrying both human wild-type APP and Tau, exhibit AD-related pathologies.
Journal of Clinical Medicine, 2020 • December 18, 2020
The study aimed to identify cellular phenotypes in ADHD patient-derived cellular models from carriers of rare copy number variants (CNVs) in the PARK2 locus. Human-derived fibroblasts (HDF) and human-...
KEY FINDING: Changes were found in PARK2 gene and protein expression in PARK2 CNV deletion and duplication carriers with ADHD compared to controls.
OncoTargets and Therapy, 2020 • January 1, 2020
This study investigates the role of lncRNA LINC00691 in osteosarcoma. It demonstrates that LINC00691 expression is downregulated in osteosarcoma cells and tissues. The study reveals that LINC00691 fun...
KEY FINDING: LINC00691 expression is decreased in osteosarcoma cells compared to control cells.
iScience, 2021 • January 22, 2021
This study uses genome-scale CRISPR screening in hPSCs to identify genes that prevent lineage specification, termed lineage-specification preventing genes (LPGs). The screening revealed that LPGs are ...
KEY FINDING: A genome-scale CRISPR screen in hPSCs identified lineage-specification preventing genes (LPGs) that, when knocked out, cause the cells to differentiate into specific germ layers.
Frontiers in Molecular Biosciences, 2020 • December 17, 2020
There are no marketed and effective antiviral drug products or biologics available for the control of SARS-CoV-2, other than symptomatic clinical treatment strategies for COVID-19. The LT receptor anta...
KEY FINDING: Leukotrienes (LTs), particularly cysteinyl-leukotrienes (Cys-LTs) and their receptors, are identified as potential drug targets in modulating various aspects of COVID-19 pathology, including inflammation, thrombosis, vascular damage, and fibrotic response.
International Journal of Molecular Sciences, 2021 • December 31, 2020
This study investigates the potential of optogenetic stimulation to improve neural progenitor cell (NPC) transplantation for treating central nervous system disorders. The approach involves using blue...
KEY FINDING: Optogenetic stimulation enhances the proliferation of ChR2-NPCs. Blue light stimulation significantly increased the proliferation of ChR2-NPCs, suggesting cation influx mediated by ChR2 enhances proliferation.
Frontiers in Cell and Developmental Biology, 2020 • December 16, 2020
This study investigates the potential of NeuroD1-mediated in vivo astrocyte-to-neuron conversion as a novel approach for spinal cord repair. The researchers used AAV NeuroD1-based gene therapy to rege...
KEY FINDING: NeuroD1 can effectively convert reactive astrocytes into functional neurons in the dorsal horn of the injured spinal cord, with a conversion rate of approximately 95%.