Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,631-1,640 of 1,773 results
Scientific Reports, 2020 • October 23, 2020
This study investigates the role of cysteinyl leukotriene receptor 1 (CysLTR1) in autophagy regulation in retinal pigment epithelial (RPE) cells, which are critical for eye health and affected in dise...
KEY FINDING: CysLTR1 is expressed in polarized ARPE-19 monolayers and colocalized with β-tubulin III.
Cell Death Discovery, 2020 • September 1, 2020
This study investigates the therapeutic potential of Parthenolide (PN) in treating spinal cord injury (SCI) by modulating M1/M2 polarization of microglia/macrophages. The results show that PN improves...
KEY FINDING: PN treatment improved functional recovery following traumatic SCI, as evidenced by increased BMS scores and decreased lesion area.
J Hematol Oncol, 2020 • October 13, 2020
This study identifies MNPC, a dual inhibitor of NQO1 and GSTP1, as a potential therapeutic agent for glioblastoma (GBM). MNPC selectively inhibits the proliferation of GBM cells bearing the EGFRvIII m...
KEY FINDING: MNPC is a small molecule inhibitor that binds to both NQO1 and GSTP1 with high affinity and selectivity, inhibiting their enzymatic activities.
International Journal of Molecular Sciences, 2020 • October 21, 2020
This study investigates the therapeutic role of irisin/FNDC5 in a rat model of third-degree burn, focusing on burn-related neuropathy and its impact on pain, paresthesia, and muscle weakness. The rese...
KEY FINDING: Burn injury results in FNDC5/irisin downregulation in both the dorsal and ventral horns and decreased irisin levels in the CSF, even after wound healing.
International Journal of Molecular Sciences, 2020 • October 30, 2020
This review focuses on the mechanisms that regulate CNS regeneration, highlighting the history, recent efforts, and questions left unanswered in this field. It has been widely accepted that both extrins...
KEY FINDING: Preventing extrinsic inhibitory signals like chondroitin sulfate proteoglycans (CSPGs) and myelin-associated glycoprotein (MAG) has been one of the promising approaches to promote axon regeneration.
Dose-Response: An International Journal, 2020 • October 1, 2020
The study demonstrates that miR-152 expression is downregulated in the cartilage tissues of patients with osteoarthritis and in chondrocytes exposed to IL-1b. This downregulation suggests a potential ...
KEY FINDING: miR-152 expression is significantly lower in cartilage tissue from OA patients and in chondrocytes treated with IL-1b, suggesting its involvement in OA progression.
Heliyon, 2020 • October 29, 2020
This study investigates the function of the major vault protein (MVP) during organ regeneration using a mvp knockout zebrafish line. The results indicate that the regenerative capacities of the heart, ...
KEY FINDING: The regenerative capacity of the heart, spinal cord, and fins is preserved in mvp knockout zebrafish.
Scientific Reports, 2020 • November 20, 2020
The study aimed to investigate if DCX+ NPCs can replace lost oligodendrocytes in the hippocampal DG after cuprizone-induced demyelination. The results showed a significant cuprizone-induced depletion ...
KEY FINDING: During remyelination, the number of GFP+ NPCs co-expressing Olig2 and CC1 significantly increased in the hippocampal DG.
Nanomedicine, 2021 • February 1, 2021
This study investigates the effect of RhoA knockdown by PgP/siRhoA nanoplexes on neuroinflammation and neuronal cell survival in a rat controlled cortical impact (CCI) TBI model in vivo. RhoA knockdow...
KEY FINDING: PgP/siRhoA nanoplexes efficiently knockdown RhoA expression in the injured brain tissue, both at the mRNA and protein levels.
The Journal of Neuroscience, 2021 • January 20, 2021
This study identifies Myc as a transcriptional hub regulating regeneration-associated genes (RAGs) after preconditioning nerve injury. The research demonstrates that Myc binds to RAG promoters, and it...
KEY FINDING: Myc proto-oncogene functions as a transcriptional hub gene regulating a subset of regeneration-associated genes (RAGs) in DRGs following preconditioning injury.