Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,651-1,660 of 1,773 results
Frontiers in Microbiology, 2021 • January 8, 2021
The study optimized the CRISPR/Cas system for genome editing in Plasmodium falciparum by developing an integrating strategy (Cas9i) and adapting the CRISPR/Cpf1 system. The Cas9i system significantly ...
KEY FINDING: The Cas9i system significantly shortened the time required to generate transgenic strains of P. falciparum.
Ann Transl Med, 2020 • December 1, 2020
This study explores the therapeutic potential of extracellular vesicles (EVs) derived from skin precursor-derived Schwann cells (SKP-SCs) for promoting axonal regeneration in damaged motoneurons. The ...
KEY FINDING: SKP-SC-EVs can be internalized by neuronal cells both in vitro and in vivo, suggesting that they can deliver their cargo to the target cells.
Molecular Therapy: Methods & Clinical Development, 2021 • March 1, 2021
The study elucidates the role of the epigenetic regulatory network involving UTX/miR-24/NeuroD1 in axonal regeneration and functional recovery in mice following SCI. UTX is identified as an intrinsic ...
KEY FINDING: UTX expression is significantly increased post-SCI and represses axonal regeneration in vitro.
Nat Neurosci, 2021 • March 1, 2021
The review addresses the current understanding of reactive astrocytes, their nomenclature, and the challenges in defining their roles in CNS diseases and aging. It critiques the oversimplified binary ...
KEY FINDING: Reactive astrocytes engage in molecularly defined programs involving changes in transcriptional regulation, biochemical, morphological, metabolic, and physiological remodeling, resulting in altered function.
Frontiers in Neuroscience, 2021 • February 1, 2021
This review summarizes the extrinsic and intrinsic mechanisms for central nerve regeneration, especially the roles of non-coding RNAs. After central nerve injury, many non-coding RNAs are expressed di...
KEY FINDING: miRNAs, such as microRNA-125b, can promote axon regeneration after spinal cord injury by influencing pathways like JAK/STAT and reducing apoptosis and inflammation.
Dev Cell, 2021 • March 8, 2021
This study identified an essential EMT-driving gene regulatory network that regulates differential regenerative capacity between mammals and zebrafish after SC injury. At the center of glial bridging ...
KEY FINDING: Pro-regenerative zebrafish glia activate an epithelial-to-mesenchymal transition (EMT) gene program, distinguishing them from mammalian glia.
Mol Brain, 2021 • February 4, 2021
This study systematically examined the expression pattern of Olig2, a transcription factor, in various cell types throughout the adult mouse brain and spinal cord. The research identified that Olig2 i...
KEY FINDING: Olig2 is universally expressed in oligodendrocytes and oligodendrocyte precursor cells (OPCs) but not in neurons or microglia in the adult mouse CNS.
Open Biol, 2021 • January 21, 2021
This study identifies a specific cell population, SrRCs, that responds to spinal cord injury (SCI) stress and actively participates in neuronal regeneration, primarily composed of radial glia (RGs) an...
KEY FINDING: A specific SCI-induced cell population, SrRCs, involved in neuronal regeneration.
Cell Death & Disease, 2021 • March 12, 2021
This study demonstrates that inhibiting ULK1, a key autophagic protein, using AAV.ULK1.DN promotes axonal regeneration in vitro and in vivo. The study found that AAV.ULK1.DN enhances neurite outgrowth...
KEY FINDING: AAV.ULK1.DN fosters axonal regeneration and enhances neurite outgrowth in vitro.
iScience, 2021 • February 19, 2021
The study identifies Neurod4 as a promising transcription factor for promoting neuroregeneration after spinal cord injury (SCI). Delivery of Neurod4 via a pseudotyped retroviral vector converts endoge...
KEY FINDING: Neurod4 promotes the conversion of ependymal cells to neural stem cells (NSCs) after spinal cord injury.