Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,591-1,600 of 1,773 results
Cytotherapy, 2020 • May 2, 2020
This statement addresses the potential use of mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) as a therapeutic approach for COVID-19, highlighting both the promise and the potential ...
KEY FINDING: MSC-EVs do not necessarily suppress immune responses, but rather modulate them, specifically moderating acute immune responses toward regulatory responses, inducing tolerance, and restoring homeostasis.
Frontiers in Molecular Neuroscience, 2020 • April 30, 2020
This review compiles data to provide a framework for interpreting synaptic plasticity around axotomized motoneurons, dividing it into two distinct processes: rapid synapse shedding and a slower mechan...
KEY FINDING: Synaptic plasticity around axotomized motoneurons should be divided into two distinct processes: a rapid cell-autonomous, microglia-independent shedding of synapses and a slower microglia-dependent mechanism that permanently alters spinal cord circuitry.
International Journal of Molecular Sciences, 2020 • May 15, 2020
The study demonstrated that the association of PEAum and Paracetamol, in a low dose (5 mg/kg + 30 mg/kg), reduced hyperalgesia, mast cell activation, c-Fos and nerve growth factor (NGF) expression, ne...
KEY FINDING: PEAum–Paracetamol association reduced hyperalgesia, mast cell activation, c-Fos and nerve growth factor (NGF) expression, neural histological damage, cytokine release, and apoptosis in a rat model of sciatic nerve injury (SNI).
CNS Neuroscience & Therapeutics, 2020 • April 20, 2020
This study investigates the effects of overexpressing the transcription factors OCT4 and KLF4 on spinal cord injury (SCI) recovery in mice. The aim was to modulate astrocyte behavior to improve outcom...
KEY FINDING: Overexpression of OCT4 and KLF4 reduces glial scar formation and increases its porosity in the lesion site after SCI.
Journal of Orthopaedic Surgery and Research, 2020 • May 25, 2020
This study investigated the relationship between inflammatory responses and prognosis in spinal cord injury (SCI). The researchers found that higher serum levels of IL-4 and IL-10 were associated with...
KEY FINDING: Higher serum levels of IL-4 and IL-10 are associated with a better prognosis in SCI, suggesting they could be potential biomarkers.
STEM CELLS AND DEVELOPMENT, 2020 • May 20, 2020
This letter to the editor critically assesses a published study on the use of bone marrow mesenchymal stem cell-derived exosomes (ExoFlo) for treating severe COVID-19. The authors express concerns reg...
KEY FINDING: The letter identifies a lack of information regarding the characterization, biological properties, and therapeutic actions of the ExoFlo product used in the original study.
Redox Biology, 2020 • May 21, 2020
This study investigates how glioblastoma (GBM) cells cope with high levels of reactive oxygen species (ROS). The researchers found that C/EBPβ, a transcription factor, regulates the expression of NQO1...
KEY FINDING: C/EBPβ is highly expressed in GBM tumors and correlates with poor patient survival rates.
Exp Cell Res, 2020 • September 15, 2020
This study used single-cell transcript sequencing to identify gene expression markers for specific immune cell types, including erythrocytes, neutrophils, macrophages, and lymphocytes, in axolotl bloo...
KEY FINDING: Six cell populations were identified from peripheral leukocytes presenting gene expression patterns indicative of erythrocyte, thrombocyte, neutrophil, B-cell, T-cell, and myeloid cell populations.
Cerebral Cortex, 2020 • November 1, 2020
This study investigates the role of semaphorins in axon repulsion after spinal cord injury (SCI), identifying that the expression of multiple semaphorin family members is induced by Olig2. Genetic evi...
KEY FINDING: Expression of multiple semaphorin family members (Sema3a, Sema3b, Sema3c, Sema3d, Sema3g, Sema4c, Sema4d, Sema5a, Sema6a, and Sema6d) was elevated one week post-injury in mice.
Oxidative Medicine and Cellular Longevity, 2020 • May 22, 2020
This study investigates the neuroprotective effects of Baicalin in Parkinson's disease (PD) using both in vitro and in vivo models. The research identifies that C/EBPβ expression is upregulated in PD ...
KEY FINDING: Baicalin protects dopaminergic neurons against reactive oxygen species (ROS) and decreases C/EBPβ and α-synuclein expression in pLVX-Tet3G-α-synuclein SH-SY5Y cells in vitro.