Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,581-1,590 of 1,773 results
Neurotherapeutics, 2020 • April 22, 2020
The study explores the role of SIRT2 in motor functional recovery following peripheral nerve injury (PNI). Results indicate that inhibiting SIRT2 deacetylase activity improves motor functional recover...
KEY FINDING: SIRT2 expression and deacetylase activity increase within motoneurons after axotomy, suggesting a role in motor regeneration.
eLife, 2020 • April 27, 2020
By intersecting chromatin accessibility data with single-cell transcriptomics, we find that NPCs place an early priority on neuronal differentiation. Late in regeneration, the priority returns to prol...
KEY FINDING: NPCs place an early priority on neuronal differentiation. Late in regeneration, the priority returns to proliferation.
Scientific Reports, 2020 • May 6, 2020
This study investigates the role of miRNAs in lipedema by comparing the extracellular miRNA profiles of SVF cells from healthy individuals and lipedema patients. The results showed that sEV-contained ...
KEY FINDING: sEVs showed no significant difference in size or concentration between healthy and lipedema patients.
Molecular Therapy, 2020 • August 1, 2020
This study demonstrates the novel function of Lin28 in controlling regrowth of motor and sensory neurons in adult mammalian CNS. Upregulating Lin28a stimulated dramatic and long distance regeneration ...
KEY FINDING: Upregulation of Lin28a in transgenic mice induces significant long-distance regeneration of corticospinal axons and the optic nerve in adult mice.
Neurobiol Dis., 2020 • July 1, 2020
This study used single-cell RNA sequencing to analyze brainstem cells from wildtype and mutant SOD1 mice, identifying transcriptomic alterations in various cell types. The analysis revealed cell-type ...
KEY FINDING: The majority of brainstem cell types in SOD1 mutant mice, including astrocytes, oligodendrocytes, microglia, and neurons, showed significant transcriptomic alterations.
Frontiers in Cellular Neuroscience, 2020 • April 24, 2020
The adult mammalian central nervous system (CNS) has very limited regenerative capacity upon neural injuries or under degenerative conditions. In recent years, however, significant progress has been ma...
KEY FINDING: In vivo neural reprogramming has achieved impressive progress, ranging from generation of diverse glia-converted neurons in multiple CNS regions to functional improvements for certain neurological conditions.
Neural Regen Res, 2020 • May 11, 2020
The study aimed to analyze miRNA expression profiles and construct a miRNA regulatory pattern in a SCIRI rat model to understand the molecular mechanisms of SCIRI and facilitate the development of nov...
KEY FINDING: Several miRNAs are aberrantly expressed in rats after spinal cord ischemia-reperfusion injury (SCIRI). At 24 hours, 13 miRNAs were aberrantly expressed, including 12 upregulated miRNAs and 1 downregulated miRNA.
F1000Research, 2020 • April 22, 2020
Spinal cord injury (SCI) leads to chronic and multifaceted disability, which severely impacts the physical and mental health as well as the socio-economic status of affected individuals. Considerable ...
KEY FINDING: Gene therapy has gained promising advancement in the past decade, as six therapies have gained clinical approval for conditions such as spinal muscular atrophy or Leber’s congenital amaurosis.
Journal of Neuroinflammation, 2020 • April 13, 2020
This study investigates the role of IL-20, a proinflammatory cytokine, in spinal cord injury (SCI) in rats. The researchers examined the expression of IL-20 and its receptors after SCI and explored it...
KEY FINDING: IL-20 and its receptors are expressed in astrocytes, oligodendrocytes, and microglia in the spinal cord after SCI in rats.
Stem Cell Research & Therapy, 2020 • April 23, 2020
This study investigates the role of hepatocyte growth factor (HGF) in mesenchymal stem cell (MSC)-induced recovery in spinal cord injured (SCI) rats. The researchers found that MSCs promote neurologic...
KEY FINDING: Conditioned medium from bone marrow-derived MSCs (BMSCs) promotes neural stem cell differentiation into neurons and neurite outgrowth by inhibiting the BMP/Smad signaling pathway.