Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,601-1,610 of 1,773 results
Gene Therapy, 2021 • June 23, 2020
This study aimed to identify the optimal promoter for strong and neuron-specific transgene expression in cortical neurons, particularly layer V corticospinal neurons, using AAV1 vectors. The hSYN prom...
KEY FINDING: The mPGK and hSYN promoters activated transgenes in significantly more neurons than the sCAG and hCMV promoters.
Signal Transduction and Targeted Therapy, 2020 • June 15, 2020
This letter identifies CBP-dependent DVL2 acetylation at K68 as a novel regulator in Wnt3a-induced DVL signalosome formation. DVL2-K68 acetylation is critical for activation of downstream β-catenin si...
KEY FINDING: CBP-dependent acetylation of DVL2 at K68 promotes DVL2 signalosome formation.
EPIGENETICS, 2021 • January 2, 2021
The study examines the distinct roles of 5hmC and 5mC in spinal cord injury and regeneration, specifically in the context of a folate-induced transgenerational phenotype. It identifies more than 2,800...
KEY FINDING: Differentially hydroxymethylated regions (DhMRs) and differentially methylated regions (DMRs) are largely unique, with distinct functions in axonal regeneration.
Scientific Reports, 2020 • July 15, 2020
The study demonstrates that dCas9-KRAB, targeted to the PTEN 5′ UTR by a single gRNA, potently and specifically repressed PTEN expression at mRNA and protein level. The dCas9-KRAB system repressed PTE...
KEY FINDING: dCas9-KRAB achieved potent and specific PTEN repression in human cell line models and neural cells derived from human iPSCs, and induced histone (H)3 methylation and deacetylation at the PTEN promoter.
Frontiers in Cellular Neuroscience, 2020 • July 2, 2020
This study explored mechanisms to modify Schwann cells (SCs) and astrocytes (ASs) characteristics and adjust the SC-AS interface to improve spinal cord injury (SCI) treatment benefits. Overexpression ...
KEY FINDING: Overexpressing miR-124 in SCs (miR-124-SCs) significantly inhibited gene and protein expression levels of SC-specific markers, such as GFAP and Krox20.
BMC Musculoskeletal Disorders, 2020 • August 3, 2020
This study demonstrates that the neutrophil-to-lymphocyte ratio (NLR) at hospital admission is an independent predictor of 6-month outcomes in patients with acute cervical traumatic spinal cord injury...
KEY FINDING: Elevated NLR at admission is an independent predictor of poorer 6-month outcomes in patients with acute cervical tSCI.
Frontiers in Cellular Neuroscience, 2020 • July 3, 2020
Functional recovery after CNS injury is limited by the failure of severed axons to regenerate and form functional connections. There has been little progress in restoring function to human patients wi...
KEY FINDING: Axon resealing after injury is an active, calcium-driven process, which facilitates cytoskeletal depolymerization and repolymerization needed to form a growth cone.
BMC Genomics, 2020 • July 13, 2020
This study aimed to identify the genetic architecture of the cerebrum in chickens and compare gene expression regulation across different brain regions and somatic tissue. The study identified one can...
KEY FINDING: One candidate gene, MTF2, was identified as potentially regulating cerebrum size, and it has previous links to brain development.
PLOS ONE, 2020 • August 11, 2020
This study investigated the efficacy of nonviral retrograde gene transfer of human hepatocyte growth factor (HGF) in improving ischemic neuropathy using a rat model of ischemic-reperfusion nerve injur...
KEY FINDING: HGF gene transfer significantly improved mechanical allodynia and thermal hyperalgesia in rats with ischemic-reperfusion nerve injury (IRI).
Translational Psychiatry, 2020 • July 15, 2020
The study investigated neuroinflammatory alterations in high trait anxiety using a mouse model (HAB). Results showed increased microglial density and activity in the hippocampus of HAB mice, particula...
KEY FINDING: HAB mice exhibited enhanced density and average cell area of Iba1+ microglia in the dentate gyrus (DG) of the hippocampus compared to NAB controls.