Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,561-1,570 of 1,773 results
Communications Biology, 2020 • January 14, 2020
The review explores the diversity of regenerative mechanisms in the central nervous system across different species, focusing on the molecular control of regeneration, particularly in axolotls. It hig...
KEY FINDING: Axolotls activate glial cell division and migration to fill in the missing portion of the neural tube after spinal cord transection, making it impossible to distinguish old from new tissue morphologically.
Oxidative Medicine and Cellular Longevity, 2020 • January 7, 2020
This study investigates the role of metformin in antioxidant and neuronal regeneration after SCI, finding that it promotes microtubule stabilization and reduces apoptosis by activating the PI3K/Akt pa...
KEY FINDING: Metformin improves functional recovery after SCI in rats, as evidenced by improved BBB scores and reduced tissue damage.
International Journal of Nanomedicine, 2020 • January 21, 2020
The study aimed to enhance Schwann cell (SC) migration across astrocyte boundaries in vitro using chondroitinase ABC (ChABC)-loaded superparamagnetic nanoparticles (SPIONs) and a magnetic field (MF) t...
KEY FINDING: Magnetofection with ChABC/PEI-SPIONs significantly increased ChABC expression in SCs, which degrades chondroitin sulfate proteoglycans (CSPGs).
OncoTargets and Therapy, 2019 • December 1, 2019
This study investigates the role of miR-26a-5p in osteosarcoma cells and finds that it is highly expressed in osteosarcoma cell lines compared to noncancerous cells, suggesting its involvement in oste...
KEY FINDING: miR-26a-5p is highly expressed in osteosarcoma cell lines compared to noncancerous cells, especially in U2OS cells.
Molecular Therapy, 2020 • April 1, 2020
This study investigates the role of miR-206 in Spinal Muscular Atrophy (SMA) using a mouse model. The researchers found that miR-206 is initially upregulated in the brainstem during early motor neuron...
KEY FINDING: miR-206 is initially upregulated in the brainstem of SMA mice in the early stages of the disease, paralleling motor neuron degeneration, but downregulated in the late symptomatic phase.
Frontiers in Cell and Developmental Biology, 2020 • January 30, 2020
This study investigates the role of agrin in BoNT/A-induced nerve sprouting in rats. The aim was to determine if agrin could serve as a target for prolonging BoNT/A's effect and to understand the regu...
KEY FINDING: Agrin participates in regulating nerve sprouting after BoNT/A application, indicated by increased agrin expression at NMJs after BoNT/A injection.
Frontiers in Pharmacology, 2020 • February 11, 2020
This study investigated the mechanism of ER stress-induced apoptosis and the protective action of fibroblast growth factor 22 (FGF22) in vivo in a rat model of spinal cord injury (SCI). The results de...
KEY FINDING: FGF22 administration promoted recovery and increased neuron survival in the spinal cord lesions of model mice. The protective effect of FGF22 is related to decreased expression of CHOP, GRP78, caspase-12, XBP1, Eif-2a and Bad which are ER stress-induced apoptosis response proteins.
Frontiers in Physiology, 2020 • February 6, 2020
Oxidative stress is involved in neuroinflammation and the progression of ALS, creating a 'vicious cycle' that reduces ATP biosynthesis and increases ROS levels. Currently, there is no cure for ALS, bu...
KEY FINDING: Oxidative stress and mitochondrial dysfunction are implicated in ALS development and progression.
Heliyon, 2020 • February 25, 2020
This review examines the extracellular and intracellular molecular signaling factors that control zebrafish glial cell bridging and glial cell development in the forebrain. The review focuses on the mo...
KEY FINDING: Fgf signaling and ctgfa are required for glial bridge formation in zebrafish spinal cord regeneration.
Exp Neurol, 2020 • June 1, 2020
The review focuses on the role of chondroitin sulfate proteoglycans (CSPGs) and their interaction with the receptor protein tyrosine phosphatase sigma (PTPσ) in regulating autophagy following spinal c...
KEY FINDING: CSPGs, particularly those with CS-E sulfation, bind with high affinity to PTPσ on axonal growth cones, disrupting autophagic flux by preventing autophagosome-lysosome fusion.