Frontiers in Physiology, 2020 · DOI: 10.3389/fphys.2020.00063 · Published: February 6, 2020
Amyotrophic lateral sclerosis (ALS) is a disease where motor neurons are lost. Oxidative stress may contribute to neurodegeneration in ALS. This article explores nicotinamide riboside and pterostilbene as potential ALS therapies. Oxidative stress happens when there is an imbalance between free radical production and the body's ability to neutralize them. This imbalance can damage cells. Antioxidants are compounds that can help neutralize free radicals and reduce oxidative stress. The review examines nicotinamide riboside and pterostilbene as therapeutic strategies in ALS.
Antioxidant substances can be used as a therapeutic strategy in ALS to increase the body’s antioxidant defenses and maintain the redox balance.
Restoration of NAD+ levels by administering the precursor NR could play a key role in diseases associated with mitochondrial dysfunction and OS.
Treatment with NR and PTER is effective and safe and therefore it could be a promising therapeutic strategy in ALS, due to its action on the pathogenesis of this disease.