Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,571-1,580 of 1,773 results
International Journal of Molecular Sciences, 2020 • March 12, 2020
This study describes the development of NVP-13, a human-specific antisense oligonucleotide (ASO) drug candidate designed to inhibit TGFβ signaling by targeting TGFBR2 mRNA. Through a rigorous screenin...
KEY FINDING: The study identified NVP-13 as a highly specific and stable ASO drug candidate targeting TGFBR2 mRNA.
Biology, 2020 • March 15, 2020
This study investigated the effect of lentiviral vectors expressing Neurotrophin-3 (NT-3) and short-hairpin RNA against NG2 (NG2 sh) to enhance neurite outgrowth in in vitro and ex vivo transection inj...
KEY FINDING: Conditioned medium from cells transduced with NT-3 or shNG2 lentiviruses caused a significant increase in neurite length of primary dorsal root ganglia neurons compared to the control group in vitro.
Neural Regen Res, 2020 • February 28, 2020
Spinal cord injury (SCI) is a serious trauma leading to loss of motor and sensory functions. Autophagy, a 'self-eating' process, recycles damaged cellular components and can either help cells survive ...
KEY FINDING: Activation of autophagy flux and inhibition of apoptosis have shown neuroprotective effects in traumatic SCI.
Neural Regeneration Research, 2020 • February 28, 2020
SCI-induced neurological disability is predominantly attributed to failure of axons to regenerate in a spinal cord lesion. Recent studies have demonstrated that epigenetic regulations play pivotal rol...
KEY FINDING: Histone modifications, such as acetylation and methylation, significantly influence axon regeneration by modulating the expression of regeneration-associated genes (RAGs).
Frontiers in Neuroscience, 2020 • March 10, 2020
Glial cells play critical roles in axon growth and guidance during neurodevelopment, influencing neuronal wiring and impacting outcomes in conditions like spinal cord injury. Understanding the molecul...
KEY FINDING: Astrocytes, through cellular processes, directly interact with growing axons, with these interactions depending on cell adhesion molecules like NCAM and N-cadherin. Distinct astrocyte populations can have differential effects on axon development, either promoting or inhibiting neurite growth.
Cureus, 2020 • February 16, 2020
This study investigates gene expression modulation during spinal cord regeneration in the axolotl model using next-generation sequencing. The research identified differentially expressed genes and enr...
KEY FINDING: The data revealed 363 genes differentially expressed between zero and seven days post-amputation, mostly downregulated.
Scientific Reports, 2020 • January 1, 2020
This document is a publisher correction for an article published in Scientific Reports. The correction addresses an indexing error concerning one of the authors, Matilde de Paola. The original article...
KEY FINDING: The original article investigates the role of α-SNAP in mouse ovarian granulosa cells.
Saudi Med J, 2020 • April 1, 2020
This study investigated the effects of syringaldehyde (SA) on spinal cord ischemia (SCI) in rabbits, focusing on its impact on oxidative stress and inflammation. The researchers induced SCI in rabbits...
KEY FINDING: Syringaldehyde treatment significantly increased Glutathione peroxidase enzyme activity levels compared to the ischemia group.
J Neurosci Methods, 2020 • June 1, 2020
This study investigated the effect of different integrin binding peptides for growth and development of primary cortical neurons in vitro using an integrin-binding array platform. The study identified...
KEY FINDING: Binding peptides for integrin αvβ8, α5β1 and α3β1 particularly the former two provided superior condition for neuronal growth, survival and maturation.
Frontiers in Cellular Neuroscience, 2020 • April 3, 2020
The glial scar is primarily composed of scar-forming astrocytes and plays a crucial role in spinal cord regeneration. The glial scar plays a dual role in SCI, both protective and inhibitory, and its e...
KEY FINDING: The glial scar restricts the spread of inflammation to protect spared neural tissues after SCI.