Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,551-1,560 of 1,773 results
Biomolecules, 2019 • December 11, 2019
This review focuses on recent progress in understanding the roles of retinoic acid (RA) signaling in various developmental processes, with a particular emphasis on zebrafish models. RA signaling gradi...
KEY FINDING: RA signaling gradients control neuromesodermal progenitor (NMP) differentiation into neural or mesodermal tissues. The amount of RA present determines NMP fate.
Frontiers in Neuroscience, 2019 • November 26, 2019
This study investigates the impact of dimethylsulfoxide (DMSO) on oligodendrogenesis using adult rat neural stem and progenitor cells (NSPCs). The key finding is that DMSO inhibits oligodendrogenesis ...
KEY FINDING: A concentration of 1% DMSO robustly suppressed oligodendrogenesis and drove the fate of differentiating NSPCs toward astrogenesis.
J Transl Med, 2019 • December 20, 2019
The study systematically compares pooled HPL-based medium preparations (pHPL) and two differentially fibrinogen-depleted variants and FBS with respect to biochemical composition. Cell proliferation wa...
KEY FINDING: pHPL-supplemented media supported proliferation of WAT- and UC-derived stromal cells significantly better than FBS.
Cell Reports, 2020 • January 7, 2020
This study investigates why regeneration following spinal root avulsion is broadly unsuccessful. It identifies that regenerating DRG neurons fail to recapitulate developmental paradigms of actin-based...
KEY FINDING: Regenerating DRG sensory axons do not initiate actin-based invasion components during re-entry into the spinal cord following avulsion-like injuries.
Mol Neurobiol, 2020 • April 1, 2020
The study demonstrates that folate supplementation in parental rodents enhances spinal cord axon regeneration in multiple generations of their offspring, even without direct folate administration to t...
KEY FINDING: Folate supplementation in F0 mating rodents increases regeneration of injured spinal axons in vivo in 4 or more generations of progeny (F1-F4) in the absence of interval folate administration to the progeny.
Autophagy, 2020 • November 2, 2020
The study demonstrates that autophagy is essential for axon regeneration, with loss-of-function mutants of autophagy genes displaying impaired axon regeneration. Axon injury induces autophagy in a DLK...
KEY FINDING: Axon injury induces autophagy in neurons, characterized by an increase in autophagosomes and autolysosomes.
Frontiers in Neuroscience, 2019 • December 10, 2019
This study investigates the temporal expression of circRNAs following SCI in rats, identifying 360 differentially expressed circRNAs. The study demonstrates that circRNA_01477 plays a role in regulati...
KEY FINDING: A total of 360 differentially expressed circRNAs were identified in rats after spinal cord injury using RNA sequencing.
Front. Cell Dev. Biol., 2019 • December 20, 2019
This study demonstrates the formation of pinwheel structures in spinal cord and SVZ tissue-derived neurospheres cultured in vitro, similar to those found in the neurogenic niche of the adult brain. Th...
KEY FINDING: Spinal cord and SVZ tissue-derived neurospheres cultured in vitro form pinwheel structures reminiscent of those present in the SVZ in vivo.
J. Biol. Chem., 2020 • January 13, 2020
This study characterizes the functions of various NKX2-2 structural domains in the oligodendrocyte differentiation process, demonstrating that the CT domain, like the TN domain, also behaves as a tran...
KEY FINDING: The N-terminal Tinman domain and C-terminal domain of NKX2-2 synergistically promote oligodendrocyte differentiation.
Bioscience Reports, 2020 • February 11, 2020
This study investigates the role of M2a macrophages and Arginase 1 (Arg1) in axonal repair following spinal cord injury (SCI) in rats. The findings indicate that M2a macrophages promote Arg1 expressio...
KEY FINDING: M2a macrophages promote the expression of Arginase 1, which restores axonal regeneration.