Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,081-1,090 of 1,773 results
TISSUE ENGINEERING: Part C, 2023 • May 24, 2023
This study introduces a time- and cost-effective method for isolating single myofibers from the flexor digitorum brevis (FDB) muscle in both young and aged mice. The protocol modifications, including ...
KEY FINDING: The modified protocol significantly improves the yield of viable, intact myofibers compared to previous methods, achieving approximately 2300–3100 myofibers from two FDB muscles of a single mouse.
Front. Physiol., 2023 • April 18, 2023
This study demonstrated the participation of pericyte (PC)-derived cells in the fibrotic scar of the lesioned optic nerve (ON) using an inducible PDGFRβ-P2A-CreERT2-tdTomato lineage tracing mouse. The...
KEY FINDING: PC-derived tdTomato+ cells increased in the lesion area over time, accounting for 60%–90% of all PDGFRβ+ cells in the lesion.
Front. Neurosci., 2023 • April 21, 2023
While regenerative medicine offers hope for the development of new therapies for SCI, significant challenges still need to be overcome. Current strategies face limitations such as low cell survival rate...
KEY FINDING: Gene therapy has the potential to activate the regenerative ability of endogenous glial cells, leading to regeneration and functional recovery in various conditions.
iScience, 2023 • April 21, 2023
This study investigates the potential of prosaposin-derived 18-mer peptide (PS18) as a therapeutic agent for neural tube defects (NTDs) using a chicken model of spina bifida aperta (SBA). The intra-am...
KEY FINDING: PS18 promoted the formation of a neuroectodermal covering over the defective neural tube within 24-h after treatment, enhancing regeneration and decreasing apoptotic activity.
Frontiers in Cellular Neuroscience, 2023 • April 20, 2023
Reactive astrogliosis is a response of astrocytes to CNS disturbances, altering their numbers, morphology, and function. Single-cell transcriptomics highlights the heterogeneity of reactive astrocytes...
KEY FINDING: Single-cell transcriptomics has revealed remarkable heterogeneity of reactive astrocytes, indicating their multifaceted functions in a whole spectrum of neuropathologies, with important temporal and spatial resolution, both in the brain and in the spinal cord.
Frontiers in Neurology, 2024 • May 21, 2024
This study comprehensively analyzes the research status and frontier of miRNAs in SCI using bibliometric methods. It identifies research hotspots, trends, and potential mechanisms. The analysis reveal...
KEY FINDING: The number of related papers increased annually from 2008 to 2024, reaching 754, with a period of rapid development.
Acta Neuropathologica Communications, 2023 • January 1, 2023
The study used single-nucleus RNA sequencing to characterize human white matter glial diversity across different CNS regions (brain, cerebellum, spinal cord), age groups, and sexes. Significant region...
KEY FINDING: Region-specific oligodendrocyte precursor cells (OPCs) were identified, retaining developmental origin markers into adulthood, distinguishing them from mouse OPCs.
Research, 2023 • May 4, 2023
This study investigates the role of cholesterol homeostasis in spinal cord lesions, finding that unresolved excess myelin-derived cholesterol contributes to scar formation. The research demonstrates t...
KEY FINDING: Cholesterol crystals accumulate in spinal cord lesions of young adult mice as early as 7 days post-injury, persisting for at least 6 weeks.
Biomedicines, 2023 • April 30, 2023
This study demonstrates that intravenous infusion of autologous genetically enriched leucoconcentrate can positively impact targets distant from the primary spinal cord injury site in mini pigs. The g...
KEY FINDING: The autologous genetically enriched leucoconcentrate promoted positive remodeling of macro- and microglial cells in the lumbar spinal cord of treated mini pigs.
Oxidative Medicine and Cellular Longevity, 2023 • May 25, 2023
This review highlights the ability of C-dots to function as anti-inflammatory agents targeting inflammation-associated diseases, demonstrating their exceptional potential as nanomedicines. C-dots have...
KEY FINDING: C-dots exhibit anti-inflammatory effects in models of LPS-induced inflammation, gout, spinal cord injury, wound healing, and other diseases.