Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,071-1,080 of 1,773 results
Cell Regeneration, 2023 • March 2, 2023
This study successfully differentiated hPSCs into self-renewal hSCNPCs through hNMPs, expressing homogeneous pan-NPC markers and spinal cord specific markers. The hSCNPCs could be further differentiat...
KEY FINDING: The study established a protocol for generating hSCNPCs from hPSCs through high-purity hNMPs, showing molecular properties of the spinal cord.
Int. J. Mol. Sci., 2023 • March 8, 2023
This study introduces a novel fluorescence-based screening system for gene editing molecules targeting junctional epidermolysis bullosa (JEB). The research team successfully created a cell line that e...
KEY FINDING: The researchers successfully generated a cell line expressing a GFP-C17 fusion protein, allowing for real-time monitoring of COL17A1 expression and localization.
Int. J. Mol. Sci., 2023 • March 11, 2023
This study investigates the potential of hyperbaric oxygen therapy (HBOT) to alleviate paclitaxel-induced peripheral neuropathy (CIPN) in rats. The research focuses on the TLR4-MyD88-NF-κB signaling p...
KEY FINDING: HBOT and TAK-242 alleviated behavioral signs of CIPN, specifically mechanical allodynia and thermal hyperalgesia, in rats treated with paclitaxel and LPS.
CNS Neuroscience & Therapeutics, 2023 • January 1, 2023
The study demonstrates that TBK1-mediated innate immune responses play an important role in the activation of reactive astrocytes after SCI. Inhibition of TBK1 promotes the activation of noncanonical ...
KEY FINDING: TBK1 and TBK1-medicated innate immune pathways were activated in astrocytes and neurons after SCI.
Frontiers in Molecular Neuroscience, 2023 • March 23, 2023
The perspective is that targeting microglial ATF3 upregulation can mitigate inflammation, representing an unexplored therapeutic approach for various CNS diseases. Small molecules can induce ATF3 expr...
KEY FINDING: ATF3 functions as a negative regulator of innate immune activation, suppressing pro-inflammatory gene expression in macrophages following TLR4 activation.
Nature Communications, 2023 • April 14, 2023
The study reports on an ultra-rare, rapidly progressive form of heterotopic ossification (HO) leading to premature death due to extensive ossification of connective tissue. The unique phenotype is cau...
KEY FINDING: An inter-chromosomal insertional duplication disrupts a topologically associating domain, causing an ultra-rare progressive form of heterotopic ossification.
Hereditas, 2023 • April 3, 2023
The study investigates the mechanism by which γ-T3, a form of vitamin E, regulates gastric cancer cells, focusing on its impact on gene expression and signaling pathways. RNA-seq analysis of γ-T3-trea...
KEY FINDING: γ-T3 treatment alters the expression of mRNA and ncRNA in gastric cancer cells, indicating a broad impact on cellular functions.
Bioactive Materials, 2023 • January 1, 2023
This study developed an AP-EXO-based biological scaffold by anchoring neuron-targeting and growth-facilitating peptides, improving the targeting specificity and therapeutic efficacy of bioactive pepti...
KEY FINDING: AP-EXOR&L&S enables its homing competency to SCI injury sites where multifunctional peptide-loaded AP-EXO exerted their potential effect on SCI repair by directly targeting the lesion sites.
PLoS Biology, 2023 • April 17, 2023
This study investigates the role of RPS6 phosphorylation in axon regeneration in the peripheral and central nervous systems. It identifies that phosphorylation of RPS6, particularly at Ser235-236, is ...
KEY FINDING: RPS6 phosphorylation on Ser235-236 is essential for PNS and CNS regeneration in mice.
BMC Genomics, 2023 • April 5, 2023
This study presents a high-quality genome of Whitmania pigra, and reports a transcriptome covering the starting point of cell differentiation to individual maturation. We described the whole process o...
KEY FINDING: Five broad stages of embryogenesis were defined: cleavage stages, blastocyst stage, gastrula stage, organogenesis and refinement, juvenile.