Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,091-1,100 of 1,773 results
Neural Regeneration Research, 2023 • March 15, 2023
This study investigated the dynamic alterations of DNA methylation during SCI in mice, identifying reduced non-CpG methylation as an epigenetic target. Global DNA methylation levels decreased modestly...
KEY FINDING: Global DNA methylation levels, especially non-CpG methylation, decrease modestly after spinal cord injury in mice.
Neural Regeneration Research, 2023 • March 31, 2023
This study demonstrated the neuroprotective role of Rheb in promoting axon regeneration and increasing RGC survival after ONC. Overexpression of caRheb in RGCs activated the mTORC1 pathway, leading to...
KEY FINDING: Overexpression of constitutively active Rheb promoted survival of retinal ganglion cells in the acute (14 days) and chronic (21 and 42 days) stages of injury.
Front. Cell. Neurosci., 2023 • May 24, 2023
This review explores the dual roles of the SCI scar, recognizing its acute benefits in damage control and chronic drawbacks as an impediment to regeneration. It highlights that indiscriminate targetin...
KEY FINDING: The SCI scar plays both beneficial and harmful roles in SCI, being acutely beneficial for damage containment but chronically contributing to regeneration failure.
Frontiers in Cellular Neuroscience, 2023 • December 18, 2023
This study explores the role of the P2X7 receptor (P2X7r) in reactivating the ependymal stem cell niche in the adult spinal cord following injury. The ependyma is a latent stem cell niche that is reac...
KEY FINDING: Activation of P2X7 receptors by BzATP in vivo rescued ependymal cells from quiescence, triggering a proliferative response similar to that generated by injury.
Cells, 2023 • May 25, 2023
The study demonstrates a method for generating fate-committed Schwann cells from human bone marrow stromal cells (hBMSCs) using induced pluripotent stem-cell-derived sensory neurons (hiSNs). Transplan...
KEY FINDING: hBMSC-dSCs, when transplanted into rats with sciatic nerve injuries, significantly improved gait compared to controls, suggesting nerve regeneration.
Aging and Disease, 2024 • February 1, 2024
This review discusses the generation and action mechanisms of CSPGs for the recovery of SCI. It highlights the role of extracellular traps (ETs) in stimulating astrocytes to produce CSPGs and the vari...
KEY FINDING: Extracellular traps (ETs) released by neutrophils and microglia after SCI activate astrocytes to produce CSPGs, which inhibit axon regeneration.
Molecular Biotechnology, 2024 • June 15, 2023
This study explores the molecular mechanisms by which NT-3, combined with modulation of the TGF-β signaling pathway, can enhance spinal cord injury repair in mice. The results indicate that NT-3, part...
KEY FINDING: NT-3 and NT-3 + LY364947 groups showed significantly higher BBB scores compared to the model group, indicating improved motor function.
Cellular and Molecular Life Sciences, 2023 • June 17, 2023
The study investigated the persistence of ependymal cells in the human spinal cord during aging, examining spinal cords from 17 organ donors aged 37-83 years. The findings demonstrate that ependymal c...
KEY FINDING: FOXJ1+ cells, co-expressing SOX2 and PAX6, persist in the central region of the spinal cord throughout human life, even in donors aged 37-83 years.
Prog Neurobiol, 2023 • September 1, 2023
Neutrophils, once viewed as simple pathogen-clearing cells, are now recognized as heterogeneous and dynamic immune cells with diverse functions in the nervous system. Their involvement spans from caus...
KEY FINDING: Neutrophils are involved in both detrimental and beneficial processes in the CNS and PNS, impacting conditions such as stroke, Alzheimer's disease, multiple sclerosis, and spinal cord injury.
JOR Spine, 2023 • April 1, 2023
This study investigates the role of DLX5 in the progression of OPLL, a condition characterized by the ossification of spinal ligaments. The findings indicate that DLX5 expression is upregulated in OPL...
KEY FINDING: DLX5 is highly expressed in OPLL cells compared to non-OPLL cells, both in vitro and in vivo.