Research hotspots and trends of microRNAs in spinal cord injury: a comprehensive bibliometric analysis

Frontiers in Neurology, 2024 · DOI: 10.3389/fneur.2024.1406977 · Published: May 21, 2024

Simple Explanation

Spinal cord injury (SCI) leads to motor and sensory dysfunction, and microRNAs (miRNAs) play a key role in its treatment. This study uses bibliometrics to analyze miRNA and SCI research, providing resources for future collaboration and clinical treatment. Bibliometrics, combining qualitative and quantitative analysis, objectively summarizes multidimensional information. Tools like VOSviewer and CiteSpace help explore research trends and hotspots. This study provides a comprehensive overview of the field through bibliometric analysis of miRNA and SCI research, enhancing overall understanding of researchers and providing contemporary resources for future collaboration and clinical treatment.

Study Duration

2008 to 2024

Participants

Not specified

Evidence Level

Systematic Review

Key Findings

1
The number of related papers increased annually from 2008 to 2024, reaching 754, with a period of rapid development.
2
China has advantages in the number of national papers, citations, institutions, and authors, but needs to strengthen international cooperation.
3
Research focuses on nerve injury, apoptosis, and gene expression, while future directions involve molecular mechanisms, clinical trials, exosomes, and inflammatory reactions.

Research Summary

This study comprehensively analyzes the research status and frontier of miRNAs in SCI using bibliometric methods. It identifies research hotspots, trends, and potential mechanisms. The analysis reveals China's leading role in publication volume but highlights the need for increased international collaboration. Key research areas include inflammation, neuron protection, axon regeneration, and scar formation. Future research directions involve exosomes carrying miRNAs to inhibit inflammation for SCI treatment, with potential targets like AKT, MAPK, FOXO, and SMAD identified.

Practical Implications

Future Research

The study provides a foundation for future research in the field of miRNAs and SCI, suggesting potential targets and pathways for therapeutic intervention.

Clinical Applications

The findings may guide the development of new clinical treatments for SCI, particularly those involving exosome-based miRNA delivery.

Collaboration

The analysis emphasizes the need for strengthened international collaboration to advance miRNA research in SCI recovery.

Study Limitations

1
The included database data is relatively simple, and some other data may be ignored.
2
Excluding articles not in English may impact conclusions.
3
The database used for this study is updated in real-time and does not include papers published after the search date, which may result in differences between results at publication time and this result.

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