Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,031-1,040 of 1,773 results
EMBO Reports, 2023 • November 21, 2022
This study investigates the role of Rassf7a, a member of the Ras-association domain family, in spinal cord regeneration in zebrafish. The researchers found that zebrafish rassf7a mutants displayed sig...
KEY FINDING: Rassf7a promotes spinal cord regeneration in zebrafish. Zebrafish larvae with a rassf7a mutation exhibit defects in spinal cord regeneration and spinal neurogenesis.
J Extracell Vesicles, 2022 • November 7, 2022
This research introduces EVAnalyzer, a new open-source plugin for Fiji designed for automated single vesicle quantification from fluorescence microscopy images. The study establishes a robust procedur...
KEY FINDING: EVAnalyzer enables the automated and quantitative analysis of single vesicles from imaging data, using a robust protocol for capture, labeling, and fluorescent imaging of EVs.
International Journal of Medical Sciences, 2022 • November 14, 2022
This review summarizes the role of CXCL10 in spinal cord injury (SCI), highlighting its involvement in acute inflammatory responses, secondary damages, and complications. CXCL10, a chemokine, is upreg...
KEY FINDING: CXCL10, a chemokine, is significantly upregulated following SCI and plays a crucial role in the development of neuroinflammation.
Molecular Medicine, 2022 • December 1, 2022
This study implied that LOTUS improved Aβ-induced synapse elimination by suppressing Aβ-PirB interaction in rodents and inhibited Aβ–LilrB2 interaction in humans. PirB has been implicated in this path...
KEY FINDING: LOTUS inhibits the binding of Aβ to PirB overexpressed in Cos7 cells.
Cell Structure and Function, 2023 • December 16, 2022
The study aimed to develop a more reliable photo-activatable Gal4 transcription factor with improved light-induced gene expression and reduced dark leakage compared to existing systems. Through optimi...
KEY FINDING: eGAV exhibits significantly lower background transcription activity in dark conditions compared to hGAVPO, a commonly used PA-Gal4 transcription factor.
Frontiers in Bioengineering and Biotechnology, 2022 • December 5, 2022
The study aimed to explore a new microRNA (miRNA) which can bind to combining engineered exosomes for treatment of older OS patients. MiR-449a is down-regulated in osteosarcoma and suppresses cell pro...
KEY FINDING: MiR-449a is down-regulated in osteosarcoma and suppresses cell proliferation by targeting CCNB1.
Biology, 2022 • December 19, 2022
This study compared the efficacy of local versus systemic administration of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) in a rat model of spinal cord injury (SCI). The results indic...
KEY FINDING: Intravenous administration of MSC-EVs showed a higher success rate in improving motor function of hindlimbs compared to local administration.
Int. J. Mol. Sci., 2022 • December 13, 2022
This study investigates the effect of HPL on cell cycle gene expression in human stromal cells to identify key players mediating its growth-enhancing effects. The study found that HPL significantly af...
KEY FINDING: HPL significantly affected cell cycle-specific protein expression compared to FBS-based culture, with more genes being upregulated than downregulated.
Int. J. Mol. Sci., 2022 • December 14, 2022
This study explores the role of Anp32a in neuronal regeneration following spinal cord injury (SCI) in zebrafish embryos. Unlike mammals, zebrafish can quickly regenerate after SCI. The researchers used ...
KEY FINDING: Overexpression of Anp32a mRNA promotes spinal cord regeneration and resumption of swimming capability in zebrafish embryos after spinal cord injury.
J. Clin. Med, 2022 • December 15, 2022
Sensorineural hearing loss is a prevalent condition lacking comprehensive pharmacological treatments due to its complex molecular pathology. Extracellular vesicles (EVs) present a promising therapeuti...
KEY FINDING: Extracellular vesicles (EVs) can modulate a wide range of pathologic and physiologic pathways and can be manufactured under GMP conditions.