Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,041-1,050 of 1,773 results
Nature Communications, 2022 • December 15, 2022
The study introduces nanoHiMe-seq, a nanopore-sequencing-based method for interrogating the genome-wide localization of histone modifications and DNA methylation from single DNA molecules. nanoHiMe-se...
KEY FINDING: nanoHiMe-seq allows for the simultaneous profiling of CpG methylation and histone modifications, exhibiting utility, robustness, and sensitivity.
Neural Regeneration Research, 2023 • July 1, 2023
This study investigates the efficacy of intravenous infusion of an autologous genetically-enriched leucoconcentrate simultaneously producing recombinant VEGF, GDNF, and NCAM on the remodeling of the s...
KEY FINDING: Higher sparing of the grey matter and increased survivability of the spinal cord cells (lower number of Caspase-3-positive cells and decreased expression of Hsp27) was observed.
MOLECULAR MEDICINE REPORTS, 2015 • April 24, 2015
The present study aimed to explore potential biomarkers and molecular mechanisms underlying SCI using bioinformatic methods. DEGs were shown to be enriched in pathways associated with immune response,...
KEY FINDING: The number of DEGs decreased in a time‑dependent manner following SCI, suggesting a changing molecular environment as time progresses after the injury.
Frontiers in Bioengineering and Biotechnology, 2022 • December 16, 2022
This study found that HA treatment induces mitophagy in NPCs, preventing ROS overproduction and mitochondrial impairment, which subsequently inhibits cell apoptosis, senescence and ECM degradation via...
KEY FINDING: Hyaluronic acid (HA) can protect mitochondrial function through activation of mitophagy in nucleus pulposus cells (NPCs).
Frontiers in Cell and Developmental Biology, 2022 • December 8, 2022
This study demonstrates that Evi5 plays a crucial role in appendage regeneration in amphibians, specifically in Xenopus tadpoles. Evi5 is upregulated during limb and tail regeneration. Knockdown of Ev...
KEY FINDING: Evi5 is upregulated during limb and tail regeneration in Xenopus tadpoles, similar to its role in axolotls.
Int. J. Mol. Sci., 2023 • December 27, 2022
The study demonstrates that GDF11 exhibits neuroprotective and neurorestorative effects on the stressed spinal cord in both in vitro and in vivo models. In vitro, GDF11 enhances neuronal and oligodend...
KEY FINDING: GDF11 enhances neuronal and oligodendroglial survival in vitro while reducing microglial numbers.
J. Clin. Med., 2023 • January 2, 2023
The study classified new bone formation in OPLL into plateau-shaped and hill-shaped patterns and investigated related factors, including serum hs-CRP levels and SI joint ankylosis. The research found ...
KEY FINDING: The plateau shape of OPLL was more common in vertebral segments, while the hill shape was predominant in intervertebral regions.
Frontiers in Cellular Neuroscience, 2022 • December 22, 2022
This study explores the neurogenesis potential of OPCs derived from oligospheres and injured spinal cords, revealing differences in OPC differentiation between brain and spinal cord. The research iden...
KEY FINDING: OPCs from brain and spinal cord exhibit significant differences in differentiation and morphology.
Journal of Nanobiotechnology, 2023 • January 9, 2023
This study investigates the facilitative effect of endothelial cell-derived exosomes (EC-EXO) on Schwann cells (SCs) and the underlying mechanisms, revealing that EC-EXO boost and maintain repair-rela...
KEY FINDING: EC-EXO can boost and maintain repair-related phenotypes of SCs, enhancing axonal regeneration, myelination, and functional recovery.
Molecular Neurobiology, 2023 • January 12, 2023
This study investigates the role of astrocytic Cebpd in fibrotic scar formation after spinal cord injury (SCI). The research demonstrates that Cebpd promotes fibroblast migration and fibrotic scar for...
KEY FINDING: Deletion of Cebpd in mice resulted in decreased fibrotic scar formation after spinal cord injury.