Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,021-1,030 of 1,773 results
Oxidative Medicine and Cellular Longevity, 2022 • October 11, 2022
This study used bioinformatics analysis to identify genes associated with mitochondrial dysfunction in intervertebral disc degeneration (IDD). Datasets GSE70362 and GSE124272 were downloaded from the ...
KEY FINDING: Identified 152 differentially expressed genes (DEGs) between IDD patients and healthy controls, including 67 upregulated and 85 downregulated genes.
Cell Reports, 2022 • October 25, 2022
The study performs a genome-wide siRNA screen to identify RTN4R as a potent modifier of ataxin-2 levels. RTN4R knockdown or treatment with a peptide inhibitor is sufficient to lower ataxin-2 protein l...
KEY FINDING: Knockdown or peptide inhibition of RTN4R, the gene encoding the RTN4/NoGo-Receptor, lowers ataxin-2 protein levels in mouse and human neurons in vitro.
Development, Growth & Differentiation, 2022 • September 9, 2022
The study successfully established neural stem cell cultures from the central nervous system of the Iberian ribbed newt (Pleurodeles waltl), demonstrating the formation of neurospheres from brain- and...
KEY FINDING: Neurospheres can be generated from both brain- and spinal cord-derived cells of post-metamorphic P. waltl using a standard neurosphere culture method.
Bioactive Materials, 2023 • January 1, 2023
This review provides an overview of the role of EVs in OA, focusing on the pathogenesis, diagnosis, and treatment, while considering the associated challenges and limitations. The review summarizes th...
KEY FINDING: EVs play a significant role in OA pathogenesis by influencing inflammation, metabolism, and cellular senescence within joint tissues.
Biomedicines, 2022 • October 27, 2022
This study investigates the effects of exogenous FGF-1 on oligodendrocyte replenishment in a spinal cord injury (SCI) model and cultured cells. The research focuses on understanding how FGF-1 influenc...
KEY FINDING: FGF-1 treatment resulted in a reduction in the number of NG2+OX42−OPCs at the injury site, indicating a decrease in the accumulation of oligodendrocyte progenitor cells.
Communications Biology, 2022 • December 9, 2022
This study investigates the role of stromal cells in immune responses, focusing on the guanine-exchange factor DOCK2. The researchers used iPSC technology and genetic manipulation to identify DOCK2 as...
KEY FINDING: DOCK2 regulates immunosuppressive function in human stromal cell models.
Advanced Science, 2023 • November 16, 2022
This study identifies cancer cell lines that are sensitive or resistant to OXPHOS inhibition and reveals that the NNMT-DNMT1 axis plays a critical role in determining cancer cell reliance on mitochond...
KEY FINDING: OXPHOS inhibition-sensitive cancer cells exhibit increased OXPHOS activity and silenced NNMT expression.
Biomedicines, 2022 • December 8, 2022
This review discusses the detailed mechanisms of various molecular pathways involved in axonal regeneration, emphasizing key players that could be valuable therapeutic targets for quick axonal healing...
KEY FINDING: The review identifies various molecular pathways activated after nerve injury, such as cAMP, MAPK, and RhoA/ROCK/LIMK, as significant in axonal regeneration.
Medicine, 2022 • November 1, 2022
Spinal cord injury is a severe central nervous system injury that results in the permanent loss of motor, sensory, and autonomic functions below the level of injury with limited recovery. Secondary in...
KEY FINDING: Mitochondrial dysfunction is implicated in the initiation of neuronal damage during spinal cord ischemia and subsequent damage to the mitochondria and neuronal cell death.
Frontiers in Molecular Neuroscience, 2022 • November 3, 2022
Chronic pain (CP) is a major health problem affecting the quality of life because of the lack of understanding of the underlying pathophysiology and effective and safe treatments. NcRNAs are one of th...
KEY FINDING: MiRNAs regulate gene expression by binding to mRNAs, affecting their stability and translation, and are implicated in neuropathic pain through dysregulation in the DRG and spinal cord.