Browse the latest research summaries in the field of dermatology for spinal cord injury patients and caregivers.
Showing 161-170 of 170 results
British Journal of Dermatology, 2019 • January 1, 2019
This study presents an ex vivo RNA trans-splicing-based therapeutic approach to correct the phenotype of generalized severe epidermolysis bullosa simplex (EBS-gen sev). The researchers stably transduc...
KEY FINDING: Transplanted skin equivalents generated from trans-splicing-corrected patient keratinocytes showed a stable and blister-free epidermis.
Scientific Reports, 2018 • August 7, 2018
The study successfully delivered IFN-α mRNA to human skin explants using biolistic application. Optimized IFN-α mRNA sequence variants resulted in significantly higher IFN-α protein expression compare...
KEY FINDING: Skin explants remained viable and intact for at least five days, making them suitable for testing.
Scientific Reports, 2018 • September 12, 2018
The study demonstrates that low-dose calcipotriol can induce the expression of cathelicidin, enhance wound closure, and increase local antimicrobial defense in RDEB keratinocytes in vitro. A single-pa...
KEY FINDING: Calcipotriol treatment enhanced wound closure in RDEB cell monolayers, with up to a 2-fold increase observed in scratch closure rates.
Sci Immunol, 2019 • July 5, 2019
This study investigates the migratory behavior of human skin-resident memory T cells (TRM), challenging the concept of strict tissue compartmentalization. The research identifies a circulating populat...
KEY FINDING: Human skin CD4+ TRM can downregulate CD69 and exit the skin.
J Clin Apher, 2020 • February 1, 2020
This study evaluated the efficacy and safety of IgE-selective immunoadsorption (IA) in treating severe atopic dermatitis (AD). Five patients with severe AD underwent three courses of IA, which resulte...
KEY FINDING: IgE-selective IA effectively reduced serum IgE levels in all participants by an average of 81% per cycle.
ADVANCES IN WOUND CARE, 2020 • May 1, 2020
This study analyzes differential protein abundance of PU tissue from SCI patients using high-throughput protein identification and quantification by TMT followed by LC-MS/MS. The study identified 76 p...
KEY FINDING: The study identified 76 proteins with differences in abundance between PU and control tissue.
International Journal of Molecular Sciences, 2020 • October 21, 2020
This study investigates the therapeutic role of irisin/FNDC5 in a rat model of third-degree burn, focusing on burn-related neuropathy and its impact on pain, paresthesia, and muscle weakness. The rese...
KEY FINDING: Burn injury results in FNDC5/irisin downregulation in both the dorsal and ventral horns and decreased irisin levels in the CSF, even after wound healing.
Journal of Biological Engineering, 2020 • November 5, 2020
This study was designed to develop hybrid fiber mat compose of Ch, PVA and silk through co-electrospining process to evaluate their synergic effect on wound healing process. The Ch-PVA + Silk hybrid f...
KEY FINDING: The Ch-PVA + Silk hybrid fiber prominently showed superior mechanical properties and desire swelling as well as hydrophilic microenvironment to those of pure PVA and Ch-PVA fibers.
TheScientificWorldJOURNAL, 2006 • May 5, 2006
The review explores the regenerative capabilities of axolotls, focusing on limb regeneration and its similarities to development and wound healing. It emphasizes the biphasic nature of regeneration, t...
KEY FINDING: Limb regeneration is a biphasic process involving a preparation phase (similar to wound healing) and a redevelopment phase (similar to development).
Regen Med, 2009 • March 1, 2009
The study demonstrates that a Cx43 carboxyl-terminal peptide (ACT1) can accelerate wound closure and improve the quality of skin healing in both mouse and pig models. ACT1 treatment leads to reduced i...
KEY FINDING: Cx43 CT-peptide prompted decreases in area of scar progenitor tissue and promoted restoration of dermal histoarchitecture and mechanical strength following wounding of skin.