Browse the latest research summaries in the field of dermatology for spinal cord injury patients and caregivers.
Showing 141-150 of 170 results
The Journal of Spinal Cord Medicine, 2013 • May 1, 2013
This study investigated skin thickness over bony prominences in patients with SCI using ultrasonography, comparing them to healthy controls. The objective was to determine if ultrasound could detect d...
KEY FINDING: The skin was significantly thinner over the sacrum in SCI individuals compared with healthy volunteers.
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2013 • January 26, 2013
This study evaluated the effectiveness of a novel Chinese herbal formula, CRFSO, in treating stage IV pressure ulcers in paraplegic patients and the impact of simultaneous comprehensive rehabilitation...
KEY FINDING: CRFSO demonstrated a significantly higher healing rate (85%) compared to ARO (45.45%) after 28 days of treatment.
Top Spinal Cord Inj Rehabil, 2013 • July 1, 2013
This pilot study investigated the effects of home-based FES cycling on seat pressure in wheelchair-reliant individuals with SCI. Eight male veterans with C5-T6 SCI participated in FES cycling 3 times ...
KEY FINDING: The mean average seat pressure decreased by 3.69 ± 4.46 mm Hg after eight weeks of FES cycling.
The Journal of Spinal Cord Medicine, 2013 • November 1, 2013
Pressure ulcers are a significant challenge for SCI patients, leading to recurrent hospitalizations and high healthcare costs. Effective management requires a multidisciplinary approach, focusing on p...
KEY FINDING: Pressure ulcers in SCI patients are often located on the ischium, sacrum, trochanter, and heel, occurring when external pressure exceeds capillary pressure. Tissue injury is linked to extrinsic factors like pressure and intrinsic factors like sepsis.
Clin Trials, 2014 • April 1, 2014
The University of Southern California (USC)–Rancho Los Amigos National Rehabilitation Center (RLANRC) Pressure Ulcer Prevention Study (PUPS) aims to assess the efficacy of a lifestyle intervention in ...
KEY FINDING: The study successfully recruited 170 participants and maintained a high treatment adherence rate of 90%.
BioMed Research International, 2014 • June 26, 2014
This study explores the effects of wheelchair tilt and recline on pressure distribution in people with SCI, focusing on the Peak Pressure Index (PPI) and center of pressure. The findings indicate that...
KEY FINDING: Peak pressure displacement occurs in response to wheelchair tilt and recline, indicating that the sensel window locations for PPI calculation should be adjusted.
Stem Cell Research & Therapy, 2021 • May 14, 2021
This study explored the therapeutic effects of hADSC and hADSC-Exo on wound healing and cutaneous regeneration in a mouse model. The findings demonstrate that combined treatment with hADSC and hADSC-E...
KEY FINDING: Combined application of local hADSC-Exo smearing and hADSC/hADSC-Exo intravenous administration promoted wound healing and accelerated re-epithelialization.
Cell Tissue Res., 2022 • March 1, 2022
CNS fibrosis is no longer considered limited to penetrating injuries involving meningeal fibroblasts. Perivascular fibroblasts can form fibrotic scars in closed injuries like EAE or stroke, influenced...
KEY FINDING: Fibrotic scars in the CNS can originate from the perivascular niche, specifically from perivascular fibroblasts, even when the meninges remain intact after injury.
Theranostics, 2021 • July 25, 2021
The study demonstrates the self-assembly of skin progenitor cells into vascularized spheroid floating skin organoids (FSOs) in vitro and properly stratified rapidly vascularized human skin in vivo. Hu...
KEY FINDING: Adult and iPSC-derived fibroblasts, keratinocytes, and endothelial progenitors can self-assemble into both planar human skin in vivo and spheroid-shaped skin organoids in vitro.
Journal of Immunology Research, 2022 • February 3, 2022
This study investigates the potential of ADSC-Exos as a cell-free therapeutic strategy for immune-mediated alopecia by examining their effects on hair growth both in vitro and in vivo. The results dem...
KEY FINDING: ADSC-Exos significantly promoted DPC proliferation and migration while also reducing apoptosis in vitro.