Browse the latest research summaries in the field of dermatology for spinal cord injury patients and caregivers.
Showing 151-160 of 170 results
Frontiers in Genetics, 2022 • July 12, 2022
In this study, in total, sixteen variants were detected in twelve OCA cases including fourteen recurrent variants and two novel variants. In summary, we reported sixteen different variants in twelve O...
KEY FINDING: Ten TYR-related and two OCA2-related patients were identified with 16 different variants with potential pathogenicity.
Stem Cell Research & Therapy, 2022 • January 1, 2022
This study explored the potential clinical application roles of hADSCs-Exos encapsulated in functional PF-127 hydrogel in wound healing. The hADSCs-Exos/PF-127 combination could promote wound healing ...
KEY FINDING: PF-127/hADSCs-Exos complexes enhanced skin wound healing, promoted re-epithelialization, increased expression of Ki67, α-SMA, and CD31, facilitated collagen synthesis (Collagen I, Collagen III), up-regulated expression of skin barrier proteins (KRT1, AQP3), and reduced inflammation (IL-6, TNF-α, CD68, CD206).
Dev Cell, 2024 • February 26, 2024
The study dissects macrophage phenotypes in spiny mice (Acomys spp.) that regenerate ear pinnae tissue versus lab mice (Mus musculus) that form scar tissue, identifying secreted factors from activated...
KEY FINDING: Acomys macrophages exhibit a muted inflammatory profile compared to Mus macrophages and secrete factors that antagonize collagen production and drive matrix remodeling.
Advanced Science, 2023 • November 24, 2022
This review summarizes the microenvironmental characteristics of DFU, presents the main progress of wound healing, and summaries the state-of-the-art therapeutic strategies for DFU. The DFU clinical t...
KEY FINDING: The review highlights the complex microenvironment of DFUs, characterized by hyperglycemia, hyperinflammation, persistent infection, hypoxia, and high protease activity, all hindering the normal wound healing process.
Pharmaceuticals, 2022 • December 19, 2022
This study explored the potential of Andrographolide (Andro) to alleviate post-operative pain in a rat model. The results showed that Andro, when administered via direct injection, significantly reduc...
KEY FINDING: Andro injections significantly reduced mechanical allodynia (pain from a stimulus that doesn't normally cause pain) compared to saline treatment.
Int. J. Mol. Sci., 2023 • March 8, 2023
This study introduces a novel fluorescence-based screening system for gene editing molecules targeting junctional epidermolysis bullosa (JEB). The research team successfully created a cell line that e...
KEY FINDING: The researchers successfully generated a cell line expressing a GFP-C17 fusion protein, allowing for real-time monitoring of COL17A1 expression and localization.
Bioactive Materials, 2023 • April 2, 2023
This review provides a comprehensive overview of microneedle systems, including potential cargos, structural designs, material selection, and drug release mechanisms. The review summarizes different m...
KEY FINDING: Microneedles can easily pass through physical barriers at wound sites and sustainably release drugs, enhancing drug delivery efficiency.
Frontiers in Medicine, 2024 • January 5, 2024
The study confirmed the efficacy and safety of MPPT in treating acute and chronic wounds, including those with antimicrobial-resistant infections, in immunocompromised individuals with SCI. MPPT treat...
KEY FINDING: All acute and chronic grade 1–4 wounds and pressure ulcers in SCI patients achieved stable closure with MPPT treatment.
STEM CELLS TRANSLATIONAL MEDICINE, 2016 • July 7, 2016
The study investigates the role of umbilical cord-derived mesenchymal stem cells (uMSCs) in scar formation during wound healing, finding that uMSCs reduce scar formation and myofibroblast accumulation...
KEY FINDING: uMSCs reduced scar formation and myofibroblast accumulation in a skin-defect mouse model.
BMC Genomics, 2017 • November 21, 2017
This meta-analysis compares gene expression profiles in response to wounding across different tissues and species. The study identifies genes with significant expression changes after wounding, compar...
KEY FINDING: Transcriptomic responses in early wound healing phases showed little consistency between tissues.