Browse the latest research summaries in the field of cardiovascular science for spinal cord injury patients and caregivers.
Showing 321-330 of 339 results
Circ Res, 2015 • June 5, 2015
The autonomic nervous system intricately modulates nearly all physiological functions of the heart. Cardiac autonomic dysregulation is central to the development and progression of most cardiovascular...
KEY FINDING: Cardiac injury leads to abnormal signaling in the nervous system, resulting in excessive sympathetic activity and potentially fatal arrhythmias.
Leukemia, 2016 • January 29, 2016
This study by the European Research Initiative on CLL (ERIC) identified and validated a flow-cytometric approach to reliably quantitate CLL cells to the level of 0.0010% (10 −5). A parallel analysis o...
KEY FINDING: A six-marker flow cytometry panel (CD19, CD20, CD5, CD43, CD79b, and CD81) was identified as reliable and convenient for identifying typical CLL cells.
Frontiers in Cellular Neuroscience, 2016 • January 20, 2016
Platelets are not restricted to haemostasis; they regulate inflammation, angiogenesis, and tissue repair. Neuroinflammation is relevant for CNS repair as it contributes to debris clearance and control...
KEY FINDING: Platelets accumulate in the subventricular zone (SVZ) vasculature upon demyelination, which is associated with enhanced survival of SVZ-resident neural stem cells (NSCs).
CELL CYCLE, 2016 • March 3, 2016
This study investigates the potential of hair follicle-associated pluripotent (HAP) stem cells to differentiate into cardiac muscle cells and form beating heart-muscle tissue sheets in vitro. The find...
KEY FINDING: Isoproterenol significantly enhances the differentiation of HAP stem cells into cardiac muscle cells in vitro compared to non-supplemented conditions.
PLoS ONE, 2016 • May 13, 2016
The study investigates the potential extra-cardiac growth effects of rNRG1 in mice, complementing a prior presentation of a therapeutic strategy for rNRG1 administration in pediatric patients. Results...
KEY FINDING: Administration of rNRG1 did not alter somatic growth, as measured by body weight and tibia length.
Nature Communications, 2017 • January 10, 2017
The study elucidates how developing zebrafish spinal cord neurons coordinate vessel growth by balancing neuron-derived Vegfaa and sFlt1, which restricts angiogenesis at the neurovascular interface. Lo...
KEY FINDING: Neuronal sFlt1 restricts angiogenesis around the spinal cord by limiting Vegfaa availability.
Neural Regeneration Research, 2017 • July 1, 2017
This study investigated the protective effects of aldehyde dehydrogenase 2 (ALDH2) against spinal cord ischemia/reperfusion injury (SCII) in rats. The researchers found that alcohol administration, wh...
KEY FINDING: Rats treated with alcohol after SCII induction displayed improved neurological function, as evidenced by higher Basso, Beattie, and Bresnahan (BBB) scores.
Angiogenesis, 2018 • May 1, 2018
This study investigates the impact of chronic mild hypoxia (CMH) on vascular remodeling in the spinal cord, revealing that CMH promotes endothelial proliferation, angiogenesis, and arteriogenesis. The...
KEY FINDING: Chronic mild hypoxia (CMH) promotes endothelial proliferation and increased vascularity in spinal cord blood vessels through angiogenesis and arteriogenesis.
Theranostics, 2018 • February 4, 2018
This study investigates the hemocompatibility of human white adipose tissue (WAT), umbilical cord (UC), and bone marrow stromal cells (BMSC) for safer cell transplantation. The study demonstrates that...
KEY FINDING: Bone marrow stromal cells (BMSCs) exhibit significantly lower tissue factor (TF) expression compared to white adipose tissue (WAT) and umbilical cord (UC) stromal cells.
Cardiovasc Diabetol, 2018 • May 10, 2018
This study investigated the effect of linagliptin on endothelial function and postprandial lipid levels in subjects with coronary artery disease (CAD) and early type 2 diabetes mellitus (T2DM). The re...
KEY FINDING: Linagliptin treatment did not significantly improve flow mediated dilation (FMD) in patients with CAD and early T2DM compared to placebo.