Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 831-840 of 904 results
Methods, 2020 • January 15, 2020
Decellularization employs chemical agents, enzymes, and mechanical means to strip cells and lipids from tissue, leaving a non-immunogenic scaffold. Acellular scaffolds offer a unique material consisti...
KEY FINDING: Dysregulation of the extracellular matrix (ECM), specifically scarring, impairs normal cell function and alters the regenerative potential of nervous tissues.
TISSUE ENGINEERING: Part B, 2019 • October 23, 2019
Spinal cord injury (SCI) results in loss of motor, sensory, and autonomic functions, with limited regenerative capacity in the central nervous system (CNS). Current SCI treatment is mostly conservativ...
KEY FINDING: No effective regenerative treatment has been developed for spinal cord injury to date, despite advances in regenerative medicine and bioengineering.
CNS Neuroscience & Therapeutics, 2019 • September 1, 2019
This study aimed to assess the effectiveness of a polypyrrole/polylactic acid (PPy/PLA) nanofibrous scaffold cotransplanted with bone marrow stromal cells (BMSCs) in enhancing functional recovery in r...
KEY FINDING: The PPy/PLA/BMSCs group showed a shorter latent period compared with PPy/PLA and compared with control groups.
Scientific Reports, 2019 • September 6, 2019
This study investigates the potential of ECM hydrogels to deliver SCAP for reducing inflammation after spinal cord injury. The researchers evaluated the mechanical properties of bone and spinal cord d...
KEY FINDING: ECM hydrogels, particularly in solubilized form, can modulate inflammation in LPS-stimulated microglial cells, with spinal cord-derived hydrogels reducing the Nos2/Arg1 ratio and bone-derived hydrogels reducing Tnf expression.
Stem Cells International, 2019 • September 15, 2019
This article reviewed roles of DFCs in tooth development, their properties, and clinical application potentials, thus providing a novel guidance for tissue engineering. The establishment of tooth root...
KEY FINDING: DFCs robustly expressed parathyroid hormone-related peptide (PTHrP) during tooth root formation and after tooth eruption, and PTHrP+ DFCs differentiated into PDLCs, alveolar cryptal bone osteoblasts, and cementoblasts in acellular cementum
Neural Regeneration Research, 2020 • November 8, 2019
This study investigates the efficacy of a 3D-bioprinted collagen/silk fibroin scaffold (3D-CF) combined with neural stem cells (NSCs) in promoting nerve regeneration after spinal cord injury (SCI) in ...
KEY FINDING: Implantation of the 3D-CF combined with NSCs resulted in significantly higher neurological scores compared to other groups, indicating improved motor function recovery.
Advanced Science, 2019 • September 19, 2019
This study demonstrates the potential of tissue-engineered neural networks (NNs) to restore function after complete spinal cord injury (SCI) in canines. The NNs, derived from neural stem cells (NSCs),...
KEY FINDING: NSC-derived NN tissue transplantation showed continuous motor and sensory improvement and were eventually able to regain coordinated weight-bearing locomotion.
J Tissue Eng Regen Med, 2020 • February 5, 2020
This study demonstrates the potential of a novel integrated scaffold loaded with BMSCs to promote spinal cord regeneration through mechanical guidance and neuroprotective mechanisms. The scaffold comb...
KEY FINDING: The integrated scaffold guided the regeneration of axons, especially serotonin receptor 1A receptor-positive axonal tracts.
Frontiers in Bioengineering and Biotechnology, 2019 • November 27, 2019
The review discusses the challenges in bone regeneration, especially in patients with decreased tissue regeneration capacity. It highlights the use of mesenchymal stromal cells (MSCs) and MSC-based ti...
KEY FINDING: MSCs can be isolated from various sources, each with unique characteristics and regenerative potential, influencing the choice of cell source and manipulation techniques for specific applications.
Materials Today Bio, 2021 • January 22, 2021
Spinal cord injury (SCI) is a devastating condition with limited effective therapies. Hydrogels, with their unique properties, offer a promising avenue for delivering therapeutic agents and promoting ...
KEY FINDING: Hydrogels can be derived from natural or synthetic sources, each offering distinct advantages. Natural sources provide biocompatibility and biodegradability, while synthetic sources offer high water absorption and a wider range of chemical properties.