Regenerative Therapies for Spinal Cord Injury

Spinal cord injury is a serious condition lacking effective regenerative treatments. Recent advances in stem cell technology, biomaterials, nanotechnology, and immune engineering offer potential regenerative therapies. Combinatorial therapies leveraging multiple approaches may be necessary for satisfactory outcomes. The review focuses on minimally invasive therapies designed to promote neuroregeneration and neuroprotection after SCI. It discusses previously explored therapies, highlighting present challenges and future directions in the field. Future successful approaches for the treatment of SCI will likely include the integration of several recent advances in various fields as combinatorial therapies in minimally invasive formats.

• 1
  No effective regenerative treatment has been developed for spinal cord injury to date, despite advances in regenerative medicine and bioengineering.
• 2
  Combinatorial therapies, which simultaneously leverage multiple approaches, will likely be required to achieve satisfactory outcomes in SCI treatment.
• 3
  Minimally invasive therapies are crucial for clinical translation, reducing complications and sparing neuronal circuitry in spinal cord injury treatment.