Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 821-830 of 904 results
International Journal of Molecular Sciences, 2019 • February 2, 2019
This study investigated the use of zonal chondrocyte/mesenchymal progenitor cell constructs in minipigs for the treatment of focal cartilage defects, comparing them to non-zonal grafts and empty contr...
KEY FINDING: Both zonal and non-zonal constructs showed a significantly increased bone loss in the defects when compared to controls, suggesting an osteolytic effect of PCL-enforced implants on the subchondral bone.
Scientific Reports, 2019 • February 15, 2019
This study demonstrates that aligned microvessels can guide axon growth both in vitro and in vivo, offering a potential strategy for promoting central nervous system regeneration after injury. The res...
KEY FINDING: Aligned microvessels can effectively guide axon growth from neural progenitor cells in vitro.
J Tissue Eng Regen Med, 2019 • May 1, 2019
This study investigates a combinatorial tissue engineering approach for spinal cord injury repair, utilizing a biodegradable hydrogel scaffold, Schwann cells, and rapamycin-releasing microspheres. The...
KEY FINDING: Rapamycin, delivered locally from implanted scaffolds, reduces fibrosis and promotes functional neurologic recovery after spinal cord injury.
Scientific Reports, 2019 • February 28, 2019
This study introduces a novel two-component matrix, SPRPix, composed of recombinant spidroins and platelet-rich plasma (PRP), designed to enhance the growth and differentiation of human neural precurs...
KEY FINDING: The SPRPix matrix, combining recombinant spidroins and PRP, significantly enhanced drNPC proliferation and neuronal differentiation.
Cells, 2019 • March 23, 2019
The study investigates the impact of FM19G11-loaded gold nanoparticles (NPs) on ependymal stem progenitor cells (epSPCs) derived from G93A-SOD1 mice, an animal model of amyotrophic lateral sclerosis (...
KEY FINDING: FM19G11-loaded NPs significantly increased the percentage of epSPCs derived from 12-week-old B6.SJL and G93A-SOD1 mice after 24 and 48 hours of treatment.
PNAS, 2019 • March 28, 2019
This study introduces a synthetic, multifunctionalized hydrogel (HYDROSAP) that supports the in vitro maturation of human neural stem cells (hNSCs) into functional neuronal networks in serum-free cond...
KEY FINDING: The HYDROSAP hydrogel supported hNSC survival and differentiation into GABAergic, glutamatergic, and cholinergic neurons in vitro.
Neural Regen Res, 2019 • August 1, 2019
The review discusses the role and prospects of regenerative biomaterials in repairing spinal cord injuries (SCI). It highlights how biomaterials can address axonal junction defects and inhibitory envi...
KEY FINDING: Natural materials like collagen, chitosan, and hyaluronic acid offer good biocompatibility and biological functionality in SCI repair.
Scientific Reports, 2019 • April 1, 2019
This study introduces a chitosan-based hydrogel as a carrier for mesenchymal stem cells (MSCs) in treating spinal cord injuries (SCI). In vitro experiments demonstrated the hydrogel's biocompatibility...
KEY FINDING: Chitosan hydrogel supports MSC viability and function in vitro, allowing the cells to release therapeutic factors.
Adv. Sci., 2019 • February 27, 2019
Here, we introduce a biomimicking aligned fiber platform which allows the delivery of miRs both in vitro and in vivo in a sustained and nonviral manner. The easy incorporation of different miRs into t...
KEY FINDING: Enhanced gene-silencing is achieved in neurons as compared to conventional bolus delivery (p < 0.05).
PNAS, 2019 • July 8, 2019
This study investigates the potential for reprogramming circulating innate immune cells through nanoparticle administration to enhance functional regeneration following SCI. The nanoparticles (500 nm ...
KEY FINDING: Intravenously administered nanoparticles are internalized by circulating monocytes and neutrophils, reprogramming these cells based on their physicochemical properties.