Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 841-850 of 904 results
Conf Proc IEEE Eng Med Biol Soc, 2019 • July 1, 2019
This study investigated the effects of adding polycaprolactone (PCL) fibers to hyaluronic acid (HA) hydrogels on recovery after spinal cord injury (SCI) in rats. In this study, we evaluated the effect...
KEY FINDING: The average cystic cavity area in the SCI group was significantly higher than in the hydrogel and hydrogel + fiber groups. HE staining showed that the average cystic cavity area in the SCI (20.78 ±2.93 mm2) group was significantly higher than that in H group (6.54 ±0.85 mm2), HF group (5.06 ±0.76 mm2) and SHAM group (1.76 ±0.27 mm2) (P < 0.001).
International Journal of Nanomedicine, 2020 • January 21, 2020
The study aimed to enhance Schwann cell (SC) migration across astrocyte boundaries in vitro using chondroitinase ABC (ChABC)-loaded superparamagnetic nanoparticles (SPIONs) and a magnetic field (MF) t...
KEY FINDING: Magnetofection with ChABC/PEI-SPIONs significantly increased ChABC expression in SCs, which degrades chondroitin sulfate proteoglycans (CSPGs).
Adv Funct Mater, 2020 • January 3, 2020
3D printing offers a promising approach to neural regeneration by enabling the creation of patient-specific scaffolds with precise control over geometry, mechanics, and biology. The development of 3D ...
KEY FINDING: 3D printing offers vital features such as coupling with 3D imaging, robotics-based biomanufacturing, compatibility with multiple material sets, and rapid prototyping.
Mater Sci Eng C Mater Biol Appl, 2020 • May 1, 2020
The study evaluated the effectiveness of subcutaneously maturing NSC-seeded scaffolds, formed from MAC and containing immobilized IFN-γ, in improving locomotor function following spinal cord injury in...
KEY FINDING: Subcutaneous maturation of NSC-seeded scaffolds combined with ISP administration improved locomotor function, as assessed by BBB scores and quantitative gait parameters, compared to a no treatment control.
International Journal of Nanomedicine, 2020 • January 27, 2020
The study explores the impact of graphene oxide nanoparticle (GO NP) size on mouse neural stem cell (mNSC) fate, including self-renewal and differentiation. Results showed that GO NPs generally exhibi...
KEY FINDING: GO NPs of all sizes showed low cytotoxicity at a concentration of 20 μg/mL on the mNSCs.
Biomaterials, 2020 • July 1, 2020
This study investigates the effect of an injectable nanofiber-hydrogel composite (NHC) on neural tissue repair and regeneration in a rat model of spinal cord contusion. The NHC was designed to provide...
KEY FINDING: NHC treatment resulted in a 2-fold larger width of the contused spinal cord segment compared to controls, indicating it provided mechanical support and limited spinal cord collapse.
Soft Matter, 2020 • April 15, 2020
This study presents the synthesis of peptide-functionalized polymers containing a peptide sequence for incorporation into self-assembled peptide hydrogels, along with bioactive peptides that inhibit s...
KEY FINDING: Peptide-functionalized polymers can be integrated into self-assembled peptide hydrogels while maintaining similar mechanical properties (soft and shear-thinning) to peptide-only hydrogels.
Brazilian Journal of Medical and Biological Research, 2020 • April 1, 2020
This study investigates the potential of VPA encapsulated in PLGA microfibers, produced via coaxial electrospinning, for the treatment of spinal cord injury (SCI). The microfibers exhibited suitable m...
KEY FINDING: VPA was successfully encapsulated in PLGA microfibers using coaxial electrospinning, creating fibers with suitable morphology and mechanical characteristics for SCI applications.
Regenerative Biomaterials, 2020 • January 1, 2020
The study successfully fabricated SC-NSC core–shell fibers using a coaxial nozzle, encapsulating SCs in an alginate hydrogel shell and NSCs in the core. SCs in the shell exhibited higher expression of...
KEY FINDING: Schwann cells (SCs) encapsulated in the alginate hydrogel shell expressed more genes of neurotrophic factors compared to those cultured in petri dishes, indicating enhanced neurotrophic support.
J Neurosci Methods, 2020 • June 1, 2020
This study investigated the effect of different integrin binding peptides for growth and development of primary cortical neurons in vitro using an integrin-binding array platform. The study identified...
KEY FINDING: Binding peptides for integrin αvβ8, α5β1 and α3β1 particularly the former two provided superior condition for neuronal growth, survival and maturation.