Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 811-820 of 904 results
Cells Tissues Organs, 2018 • January 1, 2018
This review discusses how biomaterials are used to treat spinal cord injuries, emphasizing the importance of astrocytes in the healing process. It highlights that astrocytes can either help or hinder ...
KEY FINDING: Astrocytes in 3D cultures are less reactive than those in 2D cultures, which more accurately mimics healthy tissue phenotype.
Neural Regen Res, 2019 • January 1, 2019
Spinal cord injury (SCI) lacks effective treatments, necessitating regenerative strategies. Tissue engineering offers promise but faces challenges such as limited self-regeneration in the CNS. Combina...
KEY FINDING: Collagen matrices can support the growth of neurites and blood vessels in the injured spinal cord.
Adv Mater, 2019 • January 1, 2019
Advances in biomaterial synthesis, stem cell biology, bioimaging, microsurgery, and microscale technologies have made minimally invasive therapeutics a viable tool in regenerative medicine. Therapeuti...
KEY FINDING: Needles have been utilized to deliver cell-laden biomaterials into the body.
Adv Drug Deliv Rev, 2019 • August 1, 2019
This review article summarizes nanomaterial fabrication and therapeutic effects achieved by nanoscale systems in pre-clinical studies of spinal cord injury (SCI). The review specifically discusses str...
KEY FINDING: Nanocarriers enable localized, slow, and sustained delivery of therapeutics at the site of injury, overcoming limitations of systemic administration.
Tissue Eng Regen Med, 2016 • October 1, 2016
The study investigated the impact of olfactory ensheathing cell (OEC)-seeded collagen scaffolds on spinal cord injury repair in rats, focusing on axon regeneration and functional recovery. While OEC-s...
KEY FINDING: OEC-seeded scaffolds showed a trend towards improved integration and nerve regeneration, but it wasn't statistically significant.
Molecular Therapy, 2019 • February 1, 2019
This study introduces a scaffold-mediated approach for the sustained, non-viral delivery of miR-219/miR-338 to promote CNS remyelination. The aligned fiber-hydrogel scaffold was used to deliver miR-21...
KEY FINDING: miR-219/miR-338 treatment significantly enhanced OPC differentiation and maturation, leading to a greater number of mature, myelin basic protein-positive OLs compared to controls.
Nat Med, 2019 • February 1, 2019
This study demonstrates the use of rapid 3D printing to create biomimetic central nervous system structures that can be individualized and scaled to patient-specific lesion shapes and lengths. The sca...
KEY FINDING: Injured host axons regenerate into 3D biomimetic scaffolds and synapse onto NPCs implanted into the device.
International Journal of Molecular Sciences, 2019 • January 14, 2019
The review focuses on the biological properties of CaP/BG composite bone substitutes, summarizing recent experimental data to understand their osteogenic properties. BGs have limitations such as poor ...
KEY FINDING: BGs enhance osteogenic differentiation of precursor cells in vitro when added to CaPs, suggesting a synergistic effect.
Materials, 2019 • January 14, 2019
The review provides a comprehensive overview of spinal anatomy, emphasizing the structure and function of intervertebral discs. It details how these discs, composed of the annulus fibrosus, nucleus pu...
KEY FINDING: Intervertebral discs are complex structures comprised of the annulus fibrosus, nucleus pulposus, and vertebral endplates, each contributing to the disc's structural and mechanical integrity.
International Journal of Nanomedicine, 2019 • January 1, 2019
This study investigates the efficacy of a HAMC-KAFAK/BDNF hydrogel in promoting nerve regeneration in rats with spinal cord injury. The hydrogel is designed to provide sustained release of an anti-inf...
KEY FINDING: The HAMC-KAFAK/BDNF hydrogel demonstrates minimal swelling and sustained release of KAFAK and BDNF, suggesting its suitability for localized drug delivery.