Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 801-810 of 904 results
Journal of Experimental Pharmacology, 2018 • January 1, 2018
This review highlights the use of polyethylene glycol (PEG), a synthetic material known for its capacity to immediately repair physical damage and reduce local glial scar formation, and its applicatio...
KEY FINDING: PEG, as a fusogen, can repair compromised neuronal membranes in SCI, potentially by dehydrating the cell membrane or reducing surface tension.
International Journal of Molecular Sciences, 2018 • August 22, 2018
The study evaluated three methacrylate hydrogels (HPMA, HEMA, and HEMA-Fn) as bridging scaffolds in a rat model of acute spinal cord injury (SCI). HPMA and HEMA-Fn hydrogels showed better bridging qua...
KEY FINDING: HPMA and HEMA-Fn hydrogels lead to partial sensory improvement compared to control animals and animals treated with plain HEMA scaffold.
Scientific Reports, 2018 • September 4, 2018
This document is an author correction to a previously published article in Scientific Reports. The corrections address typographical errors and inaccuracies in the Introduction, Materials and Methods,...
KEY FINDING: The correction clarifies that the rapid biological clearance of agents from the body is due to degradation, reinforcing the need for biodegradable scaffolds.
Adv. Sci., 2018 • July 20, 2018
This study presents a novel spinal cord–like tissue (SCLT) assembled in vitro using neural stem cell-based tissue engineering, mimicking the white and gray matter composition of the spinal cord. The i...
KEY FINDING: The SCLT, composed of WMLT and GMLT modules, shares structural, phenotypic, and functional similarities with the adult rat spinal cord.
Adv. Sci., 2018 • July 23, 2018
The study introduces DeepScreen, a deep learning-based drug screening system utilizing convolutional neural networks and flow cytometry single-cell images, to address the limitations of traditional me...
KEY FINDING: DeepScreen demonstrates high accuracy in assessing the efficacy of drugs and nanoformulated drug systems, achieving accuracies of 0.851, 0.864, and 0.908 in testing mixed cells, HEpG2, and A549 cells, respectively.
Exp Neurol, 2019 • September 1, 2019
This review examines the use of biomaterial scaffolds as cell carriers for nerve regeneration, highlighting the challenges of treating peripheral nerve injuries with critical gaps and spinal cord inju...
KEY FINDING: Biomaterial scaffolds must be biocompatible, biodegradable, permeable/porous, biomechanically suitable, and capable of promoting cell adhesion, migration, and encapsulation to support nerve regeneration.
International Journal of Nanomedicine, 2018 • January 1, 2018
This study explores a novel tissue engineering scaffold composed of PCL electrospun fiber membrane loaded with iPSCs-NSCs and ASCs for treating spinal cord injury (SCI). The cell-containing PCL scaffo...
KEY FINDING: The iPSCs displayed similar characteristics to embryonic stem cells and were efficiently differentiated into neural stem cells in vitro.
Frontiers in Bioengineering and Biotechnology, 2018 • November 1, 2018
The study focuses on developing a tissue-specific neuronal construct using human neural precursor cells (hNPCs) on decellularized meningeal scaffolds (DMS) to support the structural and functional asp...
KEY FINDING: Decellularized meningeal scaffolds (DMS) maintain a 3D architecture and extracellular matrix (ECM), promoting long-term survival and function of neurological cells.
ACS Appl Mater Interfaces, 2019 • January 9, 2019
The study aimed to increase the versatility of aligned electrospun fiber guidance conduits by making the fibers magnetically responsive. Packaging fibers into small conduits helps maintain fiber align...
KEY FINDING: Increasing the concentration of SPIONs (superparamagnetic iron oxide nanoparticles) up to 6% by weight in PLLA (poly-L-lactic acid) fibers increases fiber magnetization without significantly altering fiber diameter, alignment, or density.
COMMUNICATIONS BIOLOGY, 2018 • December 4, 2018
The study demonstrates that a low-pressure mechanical re-adaptation device (mMS) can improve locomotor outcomes in rats after complete spinal cord transection. The mMS supports tissue preservation, ax...
KEY FINDING: mMS implantation results in a significant increase in axonal regeneration across the lesion site, invasion of glial cells and myelination of regenerating axons as well as neovascularisation throughout the implant.