Biomaterial Approaches to Modulate Reactive Astroglial Response

Biomaterials can be used to help the central nervous system repair itself after injury. These materials can deliver medicine, protect nerve cells, and encourage nerve fibers to regrow. Astrocytes, a type of brain cell, play a key role in whether the spinal cord heals well after an injury. Biomaterials should consider how astrocytes respond and promote an environment for neuron survival. Researchers need to study astrocytes more thoroughly when designing biomaterials for spinal cord injuries, as astrocytes play a crucial role in the healing process.

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  Astrocytes in 3D cultures are less reactive than those in 2D cultures, which more accurately mimics healthy tissue phenotype.
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  Hydrogel mechanical properties play an important role in the astrocyte response to these biomaterials.
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  Surface chemistry and surface patterning with ECM components impact astrocyte growth in vitro.