Author Correction: Three-dimensional aligned nanofibers-hydrogel scaffold for controlled non-viral drug/gene delivery to direct axon regeneration in spinal cord injury treatment

Scientific Reports, 2018 · DOI: 10.1038/s41598-018-31314-8 · Published: September 4, 2018

Simple Explanation

The original article contained typographical errors in the Introduction section regarding the limitations of direct administration of biological factors to injury sites and the role of miR-222 in axon regeneration. Corrections were made to the Materials and Methods section, specifically under the subheading ‘Aligned PCLEEP fibers’, concerning the synthesis of the PCLEEP copolymer. Errors in the Results and Discussion section related to scaffold analysis, delivery duration of NT-3, the role of microRNAs, and oligodendrocyte precursor cells were corrected.

Study Duration

Not specified

Participants

Not specified

Evidence Level

Not specified

Key Findings

1
The correction clarifies that the rapid biological clearance of agents from the body is due to degradation, reinforcing the need for biodegradable scaffolds.
2
The corrected text emphasizes the role of miR-222 in controlling local protein synthesis at distal axons, which is critical for axon regeneration after injuries.
3
Corrections in references ensure accuracy in attributing previous work and avoid duplication of citations.

Research Summary

This document is an author correction to a previously published article in Scientific Reports. The corrections address typographical errors and inaccuracies in the Introduction, Materials and Methods, and Results and Discussion sections. The corrections involve clarifying the reasons for using biodegradable scaffolds, the role of miR-222 in axon regeneration, and providing accurate references to previous studies. The author is correcting errors related to citation and attribution within the original paper.

Practical Implications

Improved Accuracy

Ensures the scientific community has access to accurate information regarding the use of scaffolds for drug/gene delivery in spinal cord injury treatment.

Enhanced Understanding

Clarifies the roles of biological factors and microRNAs in axon regeneration, aiding future research in this area.

Reliable Referencing

Provides correct references, preventing confusion and misattribution of research findings.

Study Limitations

1
The document only addresses corrections to the original article, not the original research itself.
2
The corrections are limited to specific sections of the paper, and may not address all potential issues.
3
The impact of these corrections on the overall conclusions of the original study is not discussed.

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