Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 791-800 of 904 results
Chinese Journal of Reparative and Reconstructive Surgery, 2018 • June 1, 2018
This article reviews the possible mechanisms of motor function recovery after complete spinal cord injury, focusing on the work of Professor Dai Jianwu's team using collagen scaffolds. The review sugg...
KEY FINDING: Long-distance regeneration of motor axons, such as CST axons, across the injury gap in complete spinal cord injury is not well-supported by objective evidence.
Chinese Journal of Reparative and Reconstructive Surgery, 2018 • June 1, 2018
This study investigates the effectiveness of linear ordered collagen scaffolds (LOCS) combined with collagen-binding domain (CBD)-BDNF in promoting axonal regeneration and motor function recovery in r...
KEY FINDING: The LOCS combined with CBD-BDNF group (Group D) showed significantly better BBB scores than the LOCS alone (Group C) or the injury-only group (Group B).
Biomaterials, 2018 • September 1, 2018
This study investigates the potential of injectable peripheral nerve (iPN) matrix to support transplanted Schwann cell (SC) survival and axon growth following spinal cord injury (SCI). The results sho...
KEY FINDING: iPN implants contained twice as many SC-myelinated axons as Matrigel grafts, indicating enhanced axon regeneration.
Scientific Reports, 2018 • July 19, 2018
This study investigates the effects of non-functionalized soft calcium alginate hydrogel implants on spinal cord injury in rats, using label-free multiphoton microscopy for detailed tissue characteriz...
KEY FINDING: Alginate hydrogel implantation led to better hindlimb function recovery in rats with spinal cord injuries compared to untreated controls, suggesting that the hydrogel has a positive effect on functional outcomes.
ACS Omega, 2017 • November 21, 2017
This study investigates the potential of reduced graphene oxide (rGO) microfibers as substrates for neural tissue engineering, particularly for spinal cord injury repair. The rGO microfibers were fabr...
KEY FINDING: rGO microfibers, when coated with neural adhesive molecules, support the formation of highly interconnected cultures of neurons and glial cells in vitro.
Neural Regeneration Research, 2018 • July 1, 2018
This study fabricated a partition-type tubular scaffold loaded with PDGF-releasing microspheres for spinal cord repair. The scaffold was designed to mimic the anatomical features of the spinal cord an...
KEY FINDING: Pre-freezing the chitosan scaffold at −20°C for 2 hours significantly increased the yield of partition-type tubular scaffolds.
International Journal of Nanomedicine, 2018 • January 1, 2018
This study introduces a novel drug delivery system utilizing dextran-based biodegradable nanoparticles to deliver paclitaxel (PTX) for treating traumatic spinal cord injury (SCI). The PTX@Ac-DEX nanop...
KEY FINDING: The prepared PTX-loaded Ac-DEX nanoparticles promoted neurite extension in the presence of CSPGs, suggesting a potential for overcoming inhibitory factors after SCI.
Acta Biomater, 2018 • September 15, 2018
The study addresses the challenge of repairing critical nerve injuries with long gaps, where traditional methods like autografts have limitations. It explores the potential of growth factors, specific...
KEY FINDING: Pleiotrophin (PTN) and glial-derived neurotrophic factor (GDNF) have a synergistic effect on axonal regeneration in vitro, promoting both sensory and motor neuron growth.
Frontiers in Neuroscience, 2018 • July 19, 2018
Recent studies have demonstrated that delivery of protein therapeutics to the spinal cord may promote functional axon regeneration, providing a pathway for recovery of certain motor skills. This persp...
KEY FINDING: Inducing axon regeneration is possible, as a 2010 study found that mice treated with IGF-1 displayed significant gains in axon number and diameter following peripheral nerve injury.
Nature Communications, 2018 • August 9, 2018
This work is based on the development of a biodegradable hybrid inorganic nanoscaffold and its utilization for the enhanced transplantation of stem cells into SCI sites. Our demonstrated nanoscaffold ...
KEY FINDING: The 3D-MnO2 nanoscaffolds can improve neuronal differentiation and neurite outgrowth, through the enhanced laminin binding and focal adhesion-related pathways.