Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 701-710 of 904 results
Materials Today Bio, 2025 • February 3, 2025
This review discusses the use of hydrogels in spinal surgery for treating intervertebral disc degeneration, spinal cord injury, and dural injury, highlighting their potential for mechanical support an...
KEY FINDING: Hydrogels can provide mechanical support to the spine, fill defects, and facilitate localized drug delivery, enhancing therapeutic effects while reducing adverse reactions.
Journal of Nanobiotechnology, 2025 • January 22, 2025
This study investigates the application of decellularized tissue matrices (DSCM) hydrogels functionalized with extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) for spinal cor...
KEY FINDING: DSCM@EVs promote NSC differentiation into neurons and suppress astrocyte formation, alleviating SCI in mice.
Journal of Nanobiotechnology, 2025 • February 11, 2025
The intestinal microbiome plays an important role in SCI and regulating intestinal microbiome promotes SCI repair. Pectin-Zein-IPA NPs treatment improves motor function recovery, inhibits the activati...
KEY FINDING: Pec-Zein-IPA NPs treatment improves motor function recovery and activates AKT/Nrf-2 signaling pathway following SCI.
Materials Today Bio, 2025 • February 4, 2025
Spinal cord injury (SCI) presents a significant neurological challenge, spurring interest in novel treatment strategies like tissue engineering and stem cell engineering. Combining drug and cell deliv...
KEY FINDING: Tissue engineering strategies can address the limitations of conventional SCI treatments by delivering drugs and cells with specific effects to the injury site.
Cell Reports Medicine, 2025 • March 18, 2025
The study develops injectable GelMA hydrogels with controlled mechanical properties containing targeting miR-222-engineered extracellular vesicles (TeEVs). These injectable patches facilitate the prec...
KEY FINDING: Targeting miR-222-engineered EVs are incorporated in mechanical GEL hydrogels
Bioactive Materials, 2025 • January 27, 2025
This review article explores the application of MXenes, a class of two-dimensional nanomaterials, in the repair and regeneration of electroactive tissues and organs. It highlights MXenes' unique physi...
KEY FINDING: MXene microelectrodes yielded higher quality neural recordings compared to gold microelectrodes due to lower neural impedance and background noise.
RSC Advances, 2025 • January 1, 2025
This review highlights the potential of graphene-based materials (GBMs) in treating spinal cord injuries (SCI) due to their unique physicochemical properties and ability to promote neural regeneration...
KEY FINDING: GBMs can be modified to enhance their biocompatibility and effectiveness in stimulating nerve regeneration.
International Journal of Nanomedicine, 2025 • April 4, 2025
The study establishes a robust framework for SCEV isolation and their comprehensive characterization, which is consistent with their therapeutic potential in neurological applications. This work provi...
KEY FINDING: The study established a reliable method for isolating SCEVs with consistent molecular profiles.
J Tissue Eng Regen Med, 2017 • January 1, 2017
This study evaluated chitosan–alginate (C–A) scaffolds in vitro for their ability to release neurotrophin-3 (NT-3) and chondroitinase ABC (chABC) in a controlled manner to augment nerve growth across ...
KEY FINDING: NT-3 was released from the C–A scaffolds for 8 weeks in vitro, while chABC was released for up to 7 weeks.
Annals of Biomedical Engineering, 2014 • October 15, 2014
This review highlights the functions and promise of self-assembled peptides for constructing bioactive matrices in regenerative medicine. Self-assembling peptides have advanced from fundamental studie...
KEY FINDING: Peptide amphiphiles (PAs) can self-assemble into nanostructures and hydrogel scaffolds for biological applications, demonstrating potential in neural, bone, and vascular regeneration.