Biomedical Research

KEY FINDING: EVsABPC significantly enhanced the proliferation of neural stem cells (NSCs) and activated neuronal regenerative potential, resulting in a 5.2-fold increase in axonal length.

KEY FINDING: The incorporation of C3 transferase mRNA into MP-LNPs does not compromise the structural integrity of the nanoparticles, ensuring efficient mRNA expression within the spinal cord.

KEY FINDING: rGO scaffolds create a permissive environment that allows the invasion of functional axonic processes from neurons located in brainstem nuclei with motor function in a rat model of complete thoracic transection.

KEY FINDING: The dynamic properties of the 3D bioprinted living fibers alleviate mechanical confinement on NSCs, enhancing their mechanosensing, spreading, migration, and matrix remodeling.

KEY FINDING: QLipTC@HDM induces M2 phenotype transformation in glial cells and in mice with SCI, thereby mitigating inflammation.

KEY FINDING: The MXene/PVA cryogel is cytocompatible and supports neural cell proliferation. Embedded MXenes did not inhibit cell growth; rather, they stimulated cell proliferation by 15–44%.

KEY FINDING: Biomaterial scaffolds can be used for drug delivery, cell load, and tissue engineering to facilitate the repair of SCIs, while acting as a scaffold and microenvironment for tissue growth with reduced inflammatory responses.

KEY FINDING: Plasma-synthesized PPy/I reduced the levels of pro-inflammatory cytokines in the experimental NHP compared to the control NHP after spinal cord transection.

KEY FINDING: The GDNF-PLNG/siMIF scaffold promotes neuron regeneration by upregulation of neuron cytokine production and inhibits inflammation through the downregulation immune pathway.

KEY FINDING: The 10 wt% Ga-MBG/TCP composite scaffold exhibited excellent biocompatibility, enhanced new bone formation, and effectively mitigated osteolysis.