Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 711-720 of 904 results
Scientific Reports, 2015 • March 12, 2015
This study investigates the potential of a bFGF-incorporated HEMA-MOETACL hydrogel implant to repair spinal cord injuries (SCI) in rats. The results demonstrate that the bFGF/HEMA-MOETACL transplant p...
KEY FINDING: The bFGF/HEMA-MOETACL transplant provided a scaffold for the ingrowth of regenerating tissue eight weeks after implantation.
PLoS ONE, 2015 • March 24, 2015
This study aimed to investigate the potential of induced neural stem cells (iNSCs) and PLGA-PEG scaffolds for tissue-engineered regeneration of completely transected spinal cords. The results demonstr...
KEY FINDING: Induced neural stem cells (iNSCs) can be generated from mouse embryonic fibroblasts (MEFs) through direct reprogramming.
Molecular Therapy, 2015 • June 1, 2015
This study demonstrates that intraspinal administration of PEG-functionalized gold nanoparticles during the acute phase after spinal cord injury is beneficial in restoring hind limb motor function. Th...
KEY FINDING: Intraspinal delivery of PEG-AuNP-40 improved hind limb motor function recovery in mice after spinal cord injury.
Tissue Engineering: Part A, 2015 • June 15, 2015
The study demonstrates a distinctive CNS tissue reaction to the implantation of OPF+ scaffolds after spinal cord injury (SCI) in rats. Scaffold implantation results in a more permissive lesion environ...
KEY FINDING: OPF+ scaffold implantation results in a more permissive lesion environment, with reduced stromal scarring, cyst formation, astrocyte reactivity, CSPG deposition, and myelin debris.
Neural Regeneration Research, 2015 • May 1, 2015
Spinal cord injury results in the permanent loss of function, causing enormous personal, social and economic problems. Even though neural regeneration has been proven to be a natural mechanism, centra...
KEY FINDING: Cell-based therapies aim at facilitating neuroregeneration, either directly via having the cells to replace and/or repair the damaged cells themselves or indirectly via secreting factors, which alter the environment, thereafter making it more conductive for regeneration.
TISSUE ENGINEERING: Part C, 2016 • January 7, 2016
This study investigates the impact of prestretch-induced surface anisotropy on axon regeneration, focusing on axon alignment, growth, and myelination. The research demonstrates that static prestretch ...
KEY FINDING: Static prestretch-induced anisotropy promotes DRG neurons to extend thicker axon aggregates along the stretched direction.
JOURNAL OF NEUROTRAUMA, 2016 • August 1, 2016
Electrospun fibers show promise as synthetic nerve guidance scaffolds due to their ability to improve axonal extension. The versatility of electrospun fibers lies in the ability to use a wide range of...
KEY FINDING: Aligned electrospun fibers can guide neurite extension from neural stem cells along the length of the fibers, similar to other engineered approaches.
Acc Chem Res, 2016 • January 19, 2016
Nanotechnology-based approaches offer precise control for stem-cell-based neural regeneration by intervening at multiple levels of scale, transitioning from soluble micro-environments to 2D micropatte...
KEY FINDING: Multifunctional magnetic core−shell nanoparticles (MCNPs) facilitate efficient siRNA transfection into primary rat NSCs (rNSCs) with minimal cytotoxicity and the ability to track transplanted cells using MRI.
TISSUE ENGINEERING: Part A, 2016 • January 28, 2016
The study evaluated the neuroregenerative potential of injectable ECM hydrogels derived from porcine spinal cord (SC-ECM) and urinary bladder (UB-ECM) in an acute spinal cord injury (SCI) model in rat...
KEY FINDING: Both SC-ECM and UB-ECM hydrogels integrated into the SCI lesion site, stimulated neovascularization, and promoted axonal ingrowth into the lesion area.
Regenerative Biomaterials, 2015 • January 13, 2015
This review discusses strategies for nervous system regeneration, focusing on biomaterials, cells, and biomolecules, particularly electrospun scaffolds, for treating nerve injuries such as peripheral ...
KEY FINDING: Nervous system injuries, including SCI and TBI, lead to significant healthcare costs and disabilities, prompting the need for improved therapies.